Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response

Impaired pancreatic β-cell survival contributes to the reduced β-cell mass in diabetes, but underlying regulatory mechanisms and key players in this process remain incompletely understood. Here, we identified the deubiquitinase ubiquitin-specific protease 1 (USP1) as an important player in the regul...

Descripción completa

Detalles Bibliográficos
Autores principales: Gorrepati, Kanaka Durga Devi, Lupse, Blaz, Annamalai, Karthika, Yuan, Ting, Maedler, Kathrin, Ardestani, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135944/
https://www.ncbi.nlm.nih.gov/pubmed/30227958
http://dx.doi.org/10.1016/j.isci.2018.02.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135944/
https://www.ncbi.nlm.nih.gov/pubmed/30227958
http://dx.doi.org/10.1016/j.isci.2018.02.003

Ejemplares similares