Cargando…

EBOVAC-Salone: Lessons learned from implementing an Ebola vaccine trial in an Ebola-affected country

BACKGROUND/AIMS: During the 2014–2016 West African Ebola epidemic, clinical trials were fast-tracked in order to identify prophylactic vaccines and experimental treatments that might be useful in preventing or treating Ebola. These trials included the ongoing EBOVAC-Salone study, which was establish...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mooney, Thomas, Smout, Elizabeth, Leigh, Bailah, Greenwood, Brian, Enria, Luisa, Ishola, David, Manno, Daniela, Samai, Mohamed, Douoguih, Macaya, Watson-Jones, Deborah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Design
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136072/ https://www.ncbi.nlm.nih.gov/pubmed/29895178 http://dx.doi.org/10.1177/1740774518780678

Ejemplares similares

Power, fairness and trust: understanding and engaging with vaccine trial participants and communities in the setting up the EBOVAC-Salone vaccine trial in Sierra Leone
por: Enria, Luisa, et al.
Publicado: (2016)

Ebola Virus Glycoprotein IgG Seroprevalence in Community Previously Affected by Ebola, Sierra Leone
por: Manno, Daniela, et al.
Publicado: (2022)

Design and analysis considerations in the Ebola_Tx trial evaluating convalescent plasma in the treatment of Ebola virus disease in Guinea during the 2014–2015 outbreak
por: Edwards, Tansy, et al.
Publicado: (2016)

Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in children in Sierra Leone: a randomised, double-blind, controlled trial
por: Afolabi, Muhammed O, et al.
Publicado: (2022)

Prevalence of malaria and helminth infections in rural communities in northern Sierra Leone, a baseline study to inform Ebola vaccine study protocols
por: Baiden, Frank, et al.
Publicado: (2022)

Safety and long-term immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Sierra Leone: a combined open-label, non-randomised stage 1, and a randomised, double-blind, controlled stage 2 trial
por: Ishola, David, et al.
Publicado: (2022)

The Effect of Previous Exposure to Malaria Infection and Clinical Malaria Episodes on the Immune Response to the Two-Dose Ad26.ZEBOV, MVA-BN-Filo Ebola Vaccine Regimen
por: Manno, Daniela, et al.
Publicado: (2023)

Immune response of a two-dose heterologous Ebola vaccine regimen: summary of three African clinical trials using a single validated Filovirus Animal Nonclinical Group enzyme-linked immunosorbent assay in a single accredited laboratory
por: McLean, Chelsea, et al.
Publicado: (2023)

Dynamics of the Humoral Immune Response to a Prime-Boost Ebola Vaccine: Quantification and Sources of Variation
por: Pasin, Chloé, et al.
Publicado: (2019)

Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries
por: Badio, Moses, et al.
Publicado: (2021)

A two-dose heterologous prime-boost vaccine regimen eliciting sustained immune responses to Ebola Zaire could support a preventive strategy for future outbreaks
por: Shukarev, Georgi, et al.
Publicado: (2016)

Correction to: Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries
por: Badio, Moses, et al.
Publicado: (2021)

It takes threat of Ebola to see lessons from low income countries
por: Harris, Matthew, et al.
Publicado: (2015)

Randomized trials of alcohol-use interventions with college students and their parents: lessons from the Transitions Project
por: Fernandez, AC, et al.
Publicado: (2011)

Antibody-Dependent Natural Killer Cell Activation After Ebola Vaccination
por: Wagstaffe, Helen R, et al.
Publicado: (2019)

Ebola or Not? Evaluating the Ill Traveler From Ebola-Affected Countries in West Africa
por: Fairley, Jessica K., et al.
Publicado: (2016)

Prediction of long-term humoral response induced by the two-dose heterologous Ad26.ZEBOV, MVA-BN-Filo vaccine against Ebola
por: Alexandre, Marie, et al.
Publicado: (2023)

Safety and Immunogenicity of a 2-Dose Heterologous Vaccination Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Uganda and Tanzania
por: Anywaine, Zacchaeus, et al.
Publicado: (2019)

Family Planning in the Sierra Leone Ebola Outbreak: Women's Proximal and Distal Reasoning
por: McKay, Gillian, et al.
Publicado: (2022)

Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer
por: Brown, Louise C, et al.
Publicado: (2022)

Durable natural killer cell responses after heterologous two-dose Ebola vaccination
por: Wagstaffe, Helen R., et al.
Publicado: (2021)

69 Preliminary Results: Prevalence and Pathophysiologic Mechanisms of Amenorrhea Among Women Survivors of the 2014–2016 Ebola Outbreak in Sierra Leone
por: Zheng, Crystal, et al.
Publicado: (2023)

Ebola virus disease in nonendemic countries
por: Wong, Samson Sai-Yin, et al.
Publicado: (2015)

Ebola: what lessons for the International Health Regulations?
por: The Lancet
Publicado: (2014)

Lessons from the public health response to Ebola
por: Robbins, Anthony, et al.
Publicado: (2014)

Beyond Ebola: lessons to mitigate future pandemics
por: Castillo-Chavez, Carlos, et al.
Publicado: (2015)

Ebola virus glycoprotein stimulates IL-18–dependent natural killer cell responses
por: Wagstaffe, Helen R., et al.
Publicado: (2020)

NK Cell Subset Redistribution and Antibody Dependent Activation after Ebola Vaccination in Africans
por: Wagstaffe, Helen R., et al.
Publicado: (2022)

Ebola and Indirect Effects on Health Service Function in Sierra Leone
por: Bolkan, Håkon Angell, et al.
Publicado: (2014)

Chromatin structure profile data from DNS-seq: Differential nuclease sensitivity mapping of four reference tissues of B73 maize (Zea mays L)
por: Turpin, Zachary M., et al.
Publicado: (2018)

Safety and Immunogenicity of Heterologous and Homologous 2-Dose Regimens of Adenovirus Serotype 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines: A Randomized, Controlled Phase 1 Study
por: Goldstein, Neil, et al.
Publicado: (2020)

The Thucydides syndrome: Ebola déjà vu? (or Ebola reemergent?)
por: Olson, P E, et al.
Publicado: (1996)

Controlling Ebola: key role of Ebola treatment centres
por: Chowell, Gerardo, et al.
Publicado: (2015)

‘No Ebola…still doomed’ – The Ebola-induced tourism crisis
por: Novelli, Marina, et al.
Publicado: (2018)

It's not Ebola … it's the systems
por: Barbiero, Victor K
Publicado: (2014)

Perspectives on Ebola
por: Rosenthal, Philip J., et al.
Publicado: (2015)

Ebola and Cholera
por: Nalin, David R., et al.
Publicado: (2015)

Etymologia: Ebola
Publicado: (2015)

Ebola and the eye
por: Clare, Gerry
Publicado: (2020)

Ebola superspreading
por: Althaus, Christian L
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hl9tiv4fgp1aoiurnttdqo8dcv