Cargando…

Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering

Human connective tissues are complex physiological microenvironments favorable for optimal survival, function, growth, proliferation, differentiation, migration, and death of tissue cells. Mimicking native tissue microenvironment using various three-dimensional (3D) tissue culture systems in vitro h...

Descripción completa

Detalles Bibliográficos
Autores principales: Rijal, Girdhari, Li, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136168/
https://www.ncbi.nlm.nih.gov/pubmed/30220913
http://dx.doi.org/10.1186/s13036-018-0114-7
_version_ 1783354945064402944
author Rijal, Girdhari
Li, Weimin
author_facet Rijal, Girdhari
Li, Weimin
author_sort Rijal, Girdhari
collection PubMed
description Human connective tissues are complex physiological microenvironments favorable for optimal survival, function, growth, proliferation, differentiation, migration, and death of tissue cells. Mimicking native tissue microenvironment using various three-dimensional (3D) tissue culture systems in vitro has been explored for decades, with great advances being achieved recently at material, design and application levels. These achievements are based on improved understandings about the functionalities of various tissue cells, the biocompatibility and biodegradability of scaffolding materials, the biologically functional factors within native tissues, and the pathophysiological conditions of native tissue microenvironments. Here we discuss these continuously evolving physical aspects of tissue microenvironment important for human disease modeling, with a focus on tumors, as well as for tissue repair and regeneration. The combined information about human tissue spaces reflects the necessities of considerations when configuring spatial microenvironments in vitro with native fidelity to culture cells and regenerate tissues that are beyond the formats of 2D and 3D cultures. It is important to associate tissue-specific cells with specific tissues and microenvironments therein for a better understanding of human biology and disease conditions and for the development of novel approaches to treat human diseases.
format Online
Article
Text
id pubmed-6136168
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-61361682018-09-15 Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering Rijal, Girdhari Li, Weimin J Biol Eng Review Human connective tissues are complex physiological microenvironments favorable for optimal survival, function, growth, proliferation, differentiation, migration, and death of tissue cells. Mimicking native tissue microenvironment using various three-dimensional (3D) tissue culture systems in vitro has been explored for decades, with great advances being achieved recently at material, design and application levels. These achievements are based on improved understandings about the functionalities of various tissue cells, the biocompatibility and biodegradability of scaffolding materials, the biologically functional factors within native tissues, and the pathophysiological conditions of native tissue microenvironments. Here we discuss these continuously evolving physical aspects of tissue microenvironment important for human disease modeling, with a focus on tumors, as well as for tissue repair and regeneration. The combined information about human tissue spaces reflects the necessities of considerations when configuring spatial microenvironments in vitro with native fidelity to culture cells and regenerate tissues that are beyond the formats of 2D and 3D cultures. It is important to associate tissue-specific cells with specific tissues and microenvironments therein for a better understanding of human biology and disease conditions and for the development of novel approaches to treat human diseases. BioMed Central 2018-09-12 /pmc/articles/PMC6136168/ /pubmed/30220913 http://dx.doi.org/10.1186/s13036-018-0114-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Rijal, Girdhari
Li, Weimin
Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
title Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
title_full Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
title_fullStr Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
title_full_unstemmed Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
title_short Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
title_sort native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136168/
https://www.ncbi.nlm.nih.gov/pubmed/30220913
http://dx.doi.org/10.1186/s13036-018-0114-7
work_keys_str_mv AT rijalgirdhari nativemimickinginvitromicroenvironmentanelusiveandseductivefuturefortumormodelingandtissueengineering
AT liweimin nativemimickinginvitromicroenvironmentanelusiveandseductivefuturefortumormodelingandtissueengineering