The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest

BACKGROUND: Nasopharyngeal carcinoma (NPC) is prevalent in South China, including Hong Kong and Southeast Asia, constantly associated with Epstein-Barr virus (EBV) infection. Epigenetic etiology attributed to EBV plays a critical role in NPC pathogenesis. Through previous CpG methylome study, we ide...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Fan, Jiangxia, Fan, Yichao, Li, Lili, He, Xiaoqian, Xiang, Qin, Mu, Junhao, Zhou, Danfeng, Sun, Xuejuan, Yang, Yucheng, Ren, Guosheng, Tao, Qian, Xiang, Tingxiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136178/
https://www.ncbi.nlm.nih.gov/pubmed/30359298
http://dx.doi.org/10.1186/s13148-018-0459-2

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