LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients

BACKGROUND: Tumor recurrence, the chief reason for poor prognosis of glioma, is largely attributed to glioma stem cells (GSCs) and epithelial-mesenchymal transition (EMT). However, the mechanisms among them remain unknown. Here, we determined whether leucine-rich repeat-containing G protein-coupled...

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Detalles Bibliográficos
Autores principales: Zhang, Jin, Cai, Hongqing, Sun, Lixin, Zhan, Panpan, Chen, Meng, Zhang, Feng, Ran, Yuliang, Wan, Jinghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136228/
https://www.ncbi.nlm.nih.gov/pubmed/30208924
http://dx.doi.org/10.1186/s13046-018-0864-6

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