HDAC4 in ischemic stroke: mechanisms and therapeutic potential

Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extremely narrow time window. Increased evidence suggests that histone deacetylase 4 (HDAC4) was...

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Autores principales: Kong, Qingsheng, Hao, Yongnan, Li, Xin, Wang, Xin, Ji, Bingyuan, Wu, Yili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136233/
https://www.ncbi.nlm.nih.gov/pubmed/30208931
http://dx.doi.org/10.1186/s13148-018-0549-1
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author Kong, Qingsheng
Hao, Yongnan
Li, Xin
Wang, Xin
Ji, Bingyuan
Wu, Yili
author_facet Kong, Qingsheng
Hao, Yongnan
Li, Xin
Wang, Xin
Ji, Bingyuan
Wu, Yili
author_sort Kong, Qingsheng
collection PubMed
description Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extremely narrow time window. Increased evidence suggests that histone deacetylase 4 (HDAC4) was dysregulated in ischemic stroke, which plays a key role in the pathogenesis of ischemic stroke and post-stroke recovery by affecting neuronal death, angiogenesis, and neurogenesis. Therefore, we aim to review the dysregulation of HDAC4 in ischemic stroke and the role of dysregulated HDAC4 in the pathogenesis of ischemic stroke. Furthermore, the therapeutic potential of modulating HDAC4 in ischemic stroke is discussed.
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spelling pubmed-61362332018-09-15 HDAC4 in ischemic stroke: mechanisms and therapeutic potential Kong, Qingsheng Hao, Yongnan Li, Xin Wang, Xin Ji, Bingyuan Wu, Yili Clin Epigenetics Review Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extremely narrow time window. Increased evidence suggests that histone deacetylase 4 (HDAC4) was dysregulated in ischemic stroke, which plays a key role in the pathogenesis of ischemic stroke and post-stroke recovery by affecting neuronal death, angiogenesis, and neurogenesis. Therefore, we aim to review the dysregulation of HDAC4 in ischemic stroke and the role of dysregulated HDAC4 in the pathogenesis of ischemic stroke. Furthermore, the therapeutic potential of modulating HDAC4 in ischemic stroke is discussed. BioMed Central 2018-09-12 /pmc/articles/PMC6136233/ /pubmed/30208931 http://dx.doi.org/10.1186/s13148-018-0549-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Kong, Qingsheng
Hao, Yongnan
Li, Xin
Wang, Xin
Ji, Bingyuan
Wu, Yili
HDAC4 in ischemic stroke: mechanisms and therapeutic potential
title HDAC4 in ischemic stroke: mechanisms and therapeutic potential
title_full HDAC4 in ischemic stroke: mechanisms and therapeutic potential
title_fullStr HDAC4 in ischemic stroke: mechanisms and therapeutic potential
title_full_unstemmed HDAC4 in ischemic stroke: mechanisms and therapeutic potential
title_short HDAC4 in ischemic stroke: mechanisms and therapeutic potential
title_sort hdac4 in ischemic stroke: mechanisms and therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136233/
https://www.ncbi.nlm.nih.gov/pubmed/30208931
http://dx.doi.org/10.1186/s13148-018-0549-1
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