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Platelet Gene Therapy Promotes Targeted Peripheral Tolerance by Clonal Deletion and Induction of Antigen-Specific Regulatory T Cells

Delivery of gene therapy as well as of biologic therapeutics is often hampered by the immune response of the subject receiving the therapy. We have reported that effective gene therapy for hemophilia utilizing platelets as a delivery vehicle engenders profound tolerance to the therapeutic product. I...

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Detalles Bibliográficos
Autores principales:	Luo, Xiaofeng, Chen, Juan, Schroeder, Jocelyn A., Allen, Kenneth P., Baumgartner, Christina K., Malarkannan, Subramaniam, Hu, Jianda, Williams, Calvin B., Shi, Qizhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136275/ https://www.ncbi.nlm.nih.gov/pubmed/30237796 http://dx.doi.org/10.3389/fimmu.2018.01950

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