Synthesis and biological evaluation of dithiocarbamate esters of parthenolide as potential anti-acute myelogenous leukaemia agents

A series of dithiocarbamate esters of parthenolide (PTL) was designed, synthesised, and evaluated for their anti- acute myelogenous leukaemia (AML) activities. The most promising compound 7l showed greatly improved potency against AML progenitor cell line KG1a with IC(50) value of 0.7 μM, and the ef...

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Detalles Bibliográficos
Autores principales: Ding, Yahui, Yang, Zhongjin, Ge, Weizhi, Kuang, Beijia, Xu, Junqing, Yang, Juan, Chen, Yue, Zhang, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136352/
https://www.ncbi.nlm.nih.gov/pubmed/30208745
http://dx.doi.org/10.1080/14756366.2018.1490734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136352/
https://www.ncbi.nlm.nih.gov/pubmed/30208745
http://dx.doi.org/10.1080/14756366.2018.1490734

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