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A case of probable oxybutynin-induced increase in liver enzymes
We describe the case of a 49-year-old male who presented to the emergency department with right-sided weakness and inability to speak. He was diagnosed with stroke and was admitted to Qatar Rehabilitation Institute after he was treated for the acute phase at Hamad General Hospital. As part of his ma...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136411/ https://www.ncbi.nlm.nih.gov/pubmed/30237720 http://dx.doi.org/10.2147/TCRM.S169868 |
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author | Alrawashdeh, Haneen Madi, Lama Ahmed Elhada, Arwa Hassan Ahmed, Afif Serheed, Dhiaddin |
author_facet | Alrawashdeh, Haneen Madi, Lama Ahmed Elhada, Arwa Hassan Ahmed, Afif Serheed, Dhiaddin |
author_sort | Alrawashdeh, Haneen |
collection | PubMed |
description | We describe the case of a 49-year-old male who presented to the emergency department with right-sided weakness and inability to speak. He was diagnosed with stroke and was admitted to Qatar Rehabilitation Institute after he was treated for the acute phase at Hamad General Hospital. As part of his management, he was started on oxybutynin 5 mg orally twice daily for the treatment of overactive bladder. Within a week, his liver enzymes started to increase. After a thorough medication review, oxybutynin was suspended as it was the only suspected medication to be responsible of this elevation in liver enzymes. When Naranjo Adverse Drug Reaction Probability Scale was used to assess the probability of an adverse drug reaction (ADR), a score of 6 was obtained indicating a “Probable” ADR. In conclusion, this is the first published report of oxybutynin-induced elevation in liver enzymes. Further reports are required to highlight this probable ADR and alert all health professionals about it. |
format | Online Article Text |
id | pubmed-6136411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61364112018-09-20 A case of probable oxybutynin-induced increase in liver enzymes Alrawashdeh, Haneen Madi, Lama Ahmed Elhada, Arwa Hassan Ahmed, Afif Serheed, Dhiaddin Ther Clin Risk Manag Case Report We describe the case of a 49-year-old male who presented to the emergency department with right-sided weakness and inability to speak. He was diagnosed with stroke and was admitted to Qatar Rehabilitation Institute after he was treated for the acute phase at Hamad General Hospital. As part of his management, he was started on oxybutynin 5 mg orally twice daily for the treatment of overactive bladder. Within a week, his liver enzymes started to increase. After a thorough medication review, oxybutynin was suspended as it was the only suspected medication to be responsible of this elevation in liver enzymes. When Naranjo Adverse Drug Reaction Probability Scale was used to assess the probability of an adverse drug reaction (ADR), a score of 6 was obtained indicating a “Probable” ADR. In conclusion, this is the first published report of oxybutynin-induced elevation in liver enzymes. Further reports are required to highlight this probable ADR and alert all health professionals about it. Dove Medical Press 2018-09-10 /pmc/articles/PMC6136411/ /pubmed/30237720 http://dx.doi.org/10.2147/TCRM.S169868 Text en © 2018 Alrawashdeh et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report Alrawashdeh, Haneen Madi, Lama Ahmed Elhada, Arwa Hassan Ahmed, Afif Serheed, Dhiaddin A case of probable oxybutynin-induced increase in liver enzymes |
title | A case of probable oxybutynin-induced increase in liver enzymes |
title_full | A case of probable oxybutynin-induced increase in liver enzymes |
title_fullStr | A case of probable oxybutynin-induced increase in liver enzymes |
title_full_unstemmed | A case of probable oxybutynin-induced increase in liver enzymes |
title_short | A case of probable oxybutynin-induced increase in liver enzymes |
title_sort | case of probable oxybutynin-induced increase in liver enzymes |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136411/ https://www.ncbi.nlm.nih.gov/pubmed/30237720 http://dx.doi.org/10.2147/TCRM.S169868 |
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