Cargando…

Targeting metastatic breast cancer with ANG1005, a novel peptide-paclitaxel conjugate that crosses the blood-brain-barrier (BBB)

We devoted this short interview piece with Dr Shou-Ching Tang at Augusta University to feature some promising results from a clinical phase II trial on a novel brain-penetrating peptide-paclitaxel-conjugate, ANG1005, in treating brain metastatic breast cancer. These results were presented by Dr. Tan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Fei, Tang, Shou-Ching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chongqing Medical University 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136589/ https://www.ncbi.nlm.nih.gov/pubmed/30258901 http://dx.doi.org/10.1016/j.gendis.2017.01.004

Ejemplares similares

Improved Antiglioblastoma Activity and BBB Permeability by Conjugation of Paclitaxel to a Cell‐Penetrative MMP‐2‐Cleavable Peptide
por: Hua, Dan, et al.
Publicado: (2020)

Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport
por: Díaz-Perlas, Cristina, et al.
Publicado: (2018)

Spontaneous penetration of gold nanoparticles through the blood brain barrier (BBB)
por: Sela, Hagit, et al.
Publicado: (2015)

Setting-up an In Vitro Model of Rat Blood-brain Barrier (BBB): A Focus on BBB Impermeability and Receptor-mediated Transport
por: Molino, Yves, et al.
Publicado: (2014)

Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1
por: Bertrand, Y, et al.
Publicado: (2011)

mPR-Specific Actions Influence Maintenance of the Blood–Brain Barrier (BBB)
por: Abou-Fadel, Johnathan, et al.
Publicado: (2022)

BBB: Permeable Conjugate of Exogenic GABA
por: Li, Qian, et al.
Publicado: (2017)

Delivery of a peptide-drug conjugate targeting the blood brain barrier improved the efficacy of paclitaxel against glioma
por: Li, Ying, et al.
Publicado: (2016)

In Vitro Study of the Effects of Angiostrongylus cantonensis Larvae Extracts on Apoptosis and Dysfunction in the Blood-Brain Barrier (BBB)
por: Hu, Xin, et al.
Publicado: (2012)

Study of BBB Dysregulation in Neuropathogenicity Using Integrative Human Model of Blood–Brain Barrier
por: Simöes Da Gama, Coraly, et al.
Publicado: (2022)

Advances in BBB on Chip and Application for Studying Reversible Opening of Blood–Brain Barrier by Sonoporation
por: Cai, Yicong, et al.
Publicado: (2022)

Micro- and Nanoplastics Breach the Blood–Brain Barrier (BBB): Biomolecular Corona’s Role Revealed
por: Kopatz, Verena, et al.
Publicado: (2023)

Cell-Penetrating and Targeted Peptides Delivery Systems as Potential Pharmaceutical Carriers for Enhanced Delivery across the Blood–Brain Barrier (BBB)
por: Ghorai, Soma Mondal, et al.
Publicado: (2023)

Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption
por: Willenbring, Robin C., et al.
Publicado: (2016)

DeePred-BBB: A Blood Brain Barrier Permeability Prediction Model With Improved Accuracy
por: Kumar, Rajnish, et al.
Publicado: (2022)

Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway
por: Zhang, Qin, et al.
Publicado: (2021)

Cabergoline possesses a beneficial effect on blood-brain barrier (BBB) integrity against lipopolysaccharide (LPS)
por: You, Lina, et al.
Publicado: (2021)

SONIC HEDGEHOG (SHH) PROMOTES BLOOD-BRAIN BARRIER (BBB) INTEGRITY IN DIFFUSE MIDLINE GLIOMA OF THE PONS
por: Line, Stacey, et al.
Publicado: (2023)

The Evolving Concept of the Blood Brain Barrier (BBB): From a Single Static Barrier to a Heterogeneous and Dynamic Relay Center
por: Villabona-Rueda, Andres, et al.
Publicado: (2019)

Micropatterned Neurovascular Interface to Mimic the Blood–Brain Barrier’s Neurophysiology and Micromechanical Function: A BBB-on-CHIP Model
por: Singh, Ajay Vikram, et al.
Publicado: (2022)

PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study
por: Hoyos-Ceballos, Gina P., et al.
Publicado: (2020)

Characteristics of (L)-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)
por: Lee, Kyeong-Eun, et al.
Publicado: (2017)

Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition
por: Sivandzade, Farzane, et al.
Publicado: (2020)

BBB-PEP-prediction: improved computational model for identification of blood–brain barrier peptides using blending position relative composition specific features and ensemble modeling
por: Naseem, Ansar, et al.
Publicado: (2023)

Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB)
por: Sekhar, Gayathri N., et al.
Publicado: (2017)

Establishing Co-Culture Blood–Brain Barrier Models for Different Neurodegeneration Conditions to Understand Its Effect on BBB Integrity
por: Park, Jun Sung, et al.
Publicado: (2023)

DUF1005 Family Identification, Evolution Analysis in Plants, and Primary Root Elongation Regulation of CiDUF1005 From Caragana intermedia
por: Tian, Xiaona, et al.
Publicado: (2022)

BBB building
por: Robinson, Richard
Publicado: (2008)

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction
por: Takata, Fuyuko, et al.
Publicado: (2021)

Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules
por: Cavaco, Marco, et al.
Publicado: (2021)

Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management
por: Hussain, Talib, et al.
Publicado: (2021)

The Role of Nanoparticle in Brain Permeability: An in-vitro BBB Model
por: Nikandish, Niusha, et al.
Publicado: (2016)

Penetrating the Blood-Brain Barrier with New Peptide–Porphyrin Conjugates Having anti-HIV Activity
por: Mendonça, Diogo A., et al.
Publicado: (2021)

Zebularine protects against blood-brain-barrier (BBB) disruption through increasing the expression of zona occludens-1 (ZO-1) and vascular endothelial (VE)-cadherin
por: Zeng, Xiangliang, et al.
Publicado: (2022)

Growth Hormone (GH) Crosses the Blood–Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury
por: Baltazar-Lara, Rosario, et al.
Publicado: (2022)

Delivering albumin-bound paclitaxel across the blood-brain barrier for gliomas
por: Gould, Andrew, et al.
Publicado: (2021)

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
por: Anraku, Y., et al.
Publicado: (2017)

Expression of VEGF and Flk-1 and Flt-1 Receptors during Blood-Brain Barrier (BBB) Impairment Following Phoneutria nigriventer Spider Venom Exposure
por: Mendonça, Monique C. P., et al.
Publicado: (2013)

Isosteviol Sodium (STVNA) Reduces Pro-Inflammatory Cytokine IL-6 and GM-CSF in an In Vitro Murine Stroke Model of the Blood–Brain Barrier (BBB)
por: Reschke, Moritz, et al.
Publicado: (2022)

Apremilast exerts protective effects on stroke outcomes and blood–brain barrier (BBB) dysfunction through regulating Rho‐associated protein kinase 2 expression
por: Wang, Mingyuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g0fropq2e40sl95h8gf3p1ngcr