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Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid gene...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Chongqing Medical University
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136593/ https://www.ncbi.nlm.nih.gov/pubmed/30258905 http://dx.doi.org/10.1016/j.gendis.2017.02.003 |
| Sumario: | Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid generation and secretion, acidification of the microenvironment and cancer immune evasion. Here we briefly review metabolic pathways generating lactate, and discuss the function of higher lactic acid in cancer microenvironments. |
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