Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment

Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid gene...

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Detalles Bibliográficos
Autor principal: Jiang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136593/
https://www.ncbi.nlm.nih.gov/pubmed/30258905
http://dx.doi.org/10.1016/j.gendis.2017.02.003
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author Jiang, Bo
author_facet Jiang, Bo
author_sort Jiang, Bo
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description Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid generation and secretion, acidification of the microenvironment and cancer immune evasion. Here we briefly review metabolic pathways generating lactate, and discuss the function of higher lactic acid in cancer microenvironments.
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spelling pubmed-61365932018-09-26 Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment Jiang, Bo Genes Dis Article Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid generation and secretion, acidification of the microenvironment and cancer immune evasion. Here we briefly review metabolic pathways generating lactate, and discuss the function of higher lactic acid in cancer microenvironments. Chongqing Medical University 2017-02-14 /pmc/articles/PMC6136593/ /pubmed/30258905 http://dx.doi.org/10.1016/j.gendis.2017.02.003 Text en Copyright © 2017, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Jiang, Bo
Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
title Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
title_full Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
title_fullStr Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
title_full_unstemmed Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
title_short Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
title_sort aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136593/
https://www.ncbi.nlm.nih.gov/pubmed/30258905
http://dx.doi.org/10.1016/j.gendis.2017.02.003
work_keys_str_mv AT jiangbo aerobicglycolysisandhighleveloflactateincancermetabolismandmicroenvironment

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