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A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow
Scrub typhus and the rickettsial diseases represent some of the oldest recognized vector-transmitted diseases, fraught with a rich historical aspect, particularly as applied to military/wartime situations. The vectors of Orientia tsutsugamushi were once thought to be confined to an area designated a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136631/ https://www.ncbi.nlm.nih.gov/pubmed/30274407 http://dx.doi.org/10.3390/tropicalmed3010008 |
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author | Luce-Fedrow, Alison Lehman, Marcie L. Kelly, Daryl J. Mullins, Kristin Maina, Alice N. Stewart, Richard L. Ge, Hong John, Heidi St. Jiang, Ju Richards, Allen L. |
author_facet | Luce-Fedrow, Alison Lehman, Marcie L. Kelly, Daryl J. Mullins, Kristin Maina, Alice N. Stewart, Richard L. Ge, Hong John, Heidi St. Jiang, Ju Richards, Allen L. |
author_sort | Luce-Fedrow, Alison |
collection | PubMed |
description | Scrub typhus and the rickettsial diseases represent some of the oldest recognized vector-transmitted diseases, fraught with a rich historical aspect, particularly as applied to military/wartime situations. The vectors of Orientia tsutsugamushi were once thought to be confined to an area designated as the Tsutsugamushi Triangle. However, recent reports of scrub typhus caused by Orientia species other than O. tsutsugamushi well beyond the limits of the Tsutsugamushi Triangle have triggered concerns about the worldwide presence of scrub typhus. It is not known whether the vectors of O. tsutsugamushi will be the same for the new Orientia species, and this should be a consideration during outbreak/surveillance investigations. Additionally, concerns surrounding the antibiotic resistance of O. tsutsugamushi have led to considerations for the amendment of treatment protocols, and the need for enhanced public health awareness in both the civilian and medical professional communities. In this review, we discuss the history, outbreaks, antibiotic resistance, and burgeoning genomic advances associated with one of the world’s oldest recognized vector-borne pathogens, O. tsutsugamushi. |
format | Online Article Text |
id | pubmed-6136631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61366312018-09-24 A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow Luce-Fedrow, Alison Lehman, Marcie L. Kelly, Daryl J. Mullins, Kristin Maina, Alice N. Stewart, Richard L. Ge, Hong John, Heidi St. Jiang, Ju Richards, Allen L. Trop Med Infect Dis Review Scrub typhus and the rickettsial diseases represent some of the oldest recognized vector-transmitted diseases, fraught with a rich historical aspect, particularly as applied to military/wartime situations. The vectors of Orientia tsutsugamushi were once thought to be confined to an area designated as the Tsutsugamushi Triangle. However, recent reports of scrub typhus caused by Orientia species other than O. tsutsugamushi well beyond the limits of the Tsutsugamushi Triangle have triggered concerns about the worldwide presence of scrub typhus. It is not known whether the vectors of O. tsutsugamushi will be the same for the new Orientia species, and this should be a consideration during outbreak/surveillance investigations. Additionally, concerns surrounding the antibiotic resistance of O. tsutsugamushi have led to considerations for the amendment of treatment protocols, and the need for enhanced public health awareness in both the civilian and medical professional communities. In this review, we discuss the history, outbreaks, antibiotic resistance, and burgeoning genomic advances associated with one of the world’s oldest recognized vector-borne pathogens, O. tsutsugamushi. MDPI 2018-01-17 /pmc/articles/PMC6136631/ /pubmed/30274407 http://dx.doi.org/10.3390/tropicalmed3010008 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Luce-Fedrow, Alison Lehman, Marcie L. Kelly, Daryl J. Mullins, Kristin Maina, Alice N. Stewart, Richard L. Ge, Hong John, Heidi St. Jiang, Ju Richards, Allen L. A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow |
title | A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow |
title_full | A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow |
title_fullStr | A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow |
title_full_unstemmed | A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow |
title_short | A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow |
title_sort | review of scrub typhus (orientia tsutsugamushi and related organisms): then, now, and tomorrow |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136631/ https://www.ncbi.nlm.nih.gov/pubmed/30274407 http://dx.doi.org/10.3390/tropicalmed3010008 |
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