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Emergence of Melioidosis in Indonesia and Today’s Challenges
A recent modeling study estimated that there could be as many as 20,000 human melioidosis cases per year in Indonesia, with around 10,000 potential deaths annually. Nonetheless, the true burden of melioidosis in Indonesia is still unknown. The Indonesia Melioidosis Network was formed during the firs...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136636/ https://www.ncbi.nlm.nih.gov/pubmed/30274429 http://dx.doi.org/10.3390/tropicalmed3010032 |
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author | Tauran, Patricia M. Wahyunie, Sri Saad, Farahanna Dahesihdewi, Andaru Graciella, Mahrany Muhammad, Munawir Lestari, Delly Chipta Aryati, Aryati Parwati, Ida Loho, Tonny Pratiwi, Dewi Indah Noviana Mutiawati, Vivi Keumala Loesnihari, Ricke Anggraini, Dewi Rahayu, Siwipeni Irmawanti Wulan, Wahyu Nawang Antonjaya, Ungke Dance, David A. B. Currie, Bart J. Limmathuthurotsakul, Direk Arif, Mansyur Aman, Abu Tholib Budayanti, Ni Nyoman Sri Iskandriati, Diah |
author_facet | Tauran, Patricia M. Wahyunie, Sri Saad, Farahanna Dahesihdewi, Andaru Graciella, Mahrany Muhammad, Munawir Lestari, Delly Chipta Aryati, Aryati Parwati, Ida Loho, Tonny Pratiwi, Dewi Indah Noviana Mutiawati, Vivi Keumala Loesnihari, Ricke Anggraini, Dewi Rahayu, Siwipeni Irmawanti Wulan, Wahyu Nawang Antonjaya, Ungke Dance, David A. B. Currie, Bart J. Limmathuthurotsakul, Direk Arif, Mansyur Aman, Abu Tholib Budayanti, Ni Nyoman Sri Iskandriati, Diah |
author_sort | Tauran, Patricia M. |
collection | PubMed |
description | A recent modeling study estimated that there could be as many as 20,000 human melioidosis cases per year in Indonesia, with around 10,000 potential deaths annually. Nonetheless, the true burden of melioidosis in Indonesia is still unknown. The Indonesia Melioidosis Network was formed during the first melioidosis workshop in 2017. Here, we reviewed 101 melioidosis cases (99 human and two animal cases) previously reported and described an additional 45 human melioidosis cases. All 146 culture-confirmed cases were found in Sumatra (n = 15), Java (n = 104), Kalimantan (n = 15), Sulawesi (n = 11) and Nusa Tenggara (n = 1). Misidentification of Burkholderia pseudomallei was not uncommon, and most cases were only recently identified. We also evaluated clinical manifestations and outcome of recent culture-confirmed cases between 2012 and 2017 (n = 42). Overall, 15 (36%) cases were children (age <15 years) and 27 (64%) were adults (age ≥15 years). The overall mortality was 43% (18/42). We conducted a survey and found that 57% (327/548) of healthcare workers had never heard of melioidosis. In conclusion, melioidosis is endemic throughout Indonesia and associated with high mortality. We propose that top priorities are increasing awareness of melioidosis amongst all healthcare workers, increasing the use of bacterial culture, and ensuring accurate identification of B. pseudomalleiand diagnosis of melioidosis. |
format | Online Article Text |
id | pubmed-6136636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61366362018-09-24 Emergence of Melioidosis in Indonesia and Today’s Challenges Tauran, Patricia M. Wahyunie, Sri Saad, Farahanna Dahesihdewi, Andaru Graciella, Mahrany Muhammad, Munawir Lestari, Delly Chipta Aryati, Aryati Parwati, Ida Loho, Tonny Pratiwi, Dewi Indah Noviana Mutiawati, Vivi Keumala Loesnihari, Ricke Anggraini, Dewi Rahayu, Siwipeni Irmawanti Wulan, Wahyu Nawang Antonjaya, Ungke Dance, David A. B. Currie, Bart J. Limmathuthurotsakul, Direk Arif, Mansyur Aman, Abu Tholib Budayanti, Ni Nyoman Sri Iskandriati, Diah Trop Med Infect Dis Article A recent modeling study estimated that there could be as many as 20,000 human melioidosis cases per year in Indonesia, with around 10,000 potential deaths annually. Nonetheless, the true burden of melioidosis in Indonesia is still unknown. The Indonesia Melioidosis Network was formed during the first melioidosis workshop in 2017. Here, we reviewed 101 melioidosis cases (99 human and two animal cases) previously reported and described an additional 45 human melioidosis cases. All 146 culture-confirmed cases were found in Sumatra (n = 15), Java (n = 104), Kalimantan (n = 15), Sulawesi (n = 11) and Nusa Tenggara (n = 1). Misidentification of Burkholderia pseudomallei was not uncommon, and most cases were only recently identified. We also evaluated clinical manifestations and outcome of recent culture-confirmed cases between 2012 and 2017 (n = 42). Overall, 15 (36%) cases were children (age <15 years) and 27 (64%) were adults (age ≥15 years). The overall mortality was 43% (18/42). We conducted a survey and found that 57% (327/548) of healthcare workers had never heard of melioidosis. In conclusion, melioidosis is endemic throughout Indonesia and associated with high mortality. We propose that top priorities are increasing awareness of melioidosis amongst all healthcare workers, increasing the use of bacterial culture, and ensuring accurate identification of B. pseudomalleiand diagnosis of melioidosis. MDPI 2018-03-13 /pmc/articles/PMC6136636/ /pubmed/30274429 http://dx.doi.org/10.3390/tropicalmed3010032 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tauran, Patricia M. Wahyunie, Sri Saad, Farahanna Dahesihdewi, Andaru Graciella, Mahrany Muhammad, Munawir Lestari, Delly Chipta Aryati, Aryati Parwati, Ida Loho, Tonny Pratiwi, Dewi Indah Noviana Mutiawati, Vivi Keumala Loesnihari, Ricke Anggraini, Dewi Rahayu, Siwipeni Irmawanti Wulan, Wahyu Nawang Antonjaya, Ungke Dance, David A. B. Currie, Bart J. Limmathuthurotsakul, Direk Arif, Mansyur Aman, Abu Tholib Budayanti, Ni Nyoman Sri Iskandriati, Diah Emergence of Melioidosis in Indonesia and Today’s Challenges |
title | Emergence of Melioidosis in Indonesia and Today’s Challenges |
title_full | Emergence of Melioidosis in Indonesia and Today’s Challenges |
title_fullStr | Emergence of Melioidosis in Indonesia and Today’s Challenges |
title_full_unstemmed | Emergence of Melioidosis in Indonesia and Today’s Challenges |
title_short | Emergence of Melioidosis in Indonesia and Today’s Challenges |
title_sort | emergence of melioidosis in indonesia and today’s challenges |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136636/ https://www.ncbi.nlm.nih.gov/pubmed/30274429 http://dx.doi.org/10.3390/tropicalmed3010032 |
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