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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number. Oncogenic KSHV induces genetic alterations through chromoso...

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Detalles Bibliográficos
Autores principales:	Lang, Fengchao, Sun, Zhiguo, Pei, Yonggang, Singh, Rajnish Kumar, Jha, Hem Chandra, Robertson, Erle S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136811/ https://www.ncbi.nlm.nih.gov/pubmed/30212568 http://dx.doi.org/10.1371/journal.ppat.1007253

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