Cargando…

Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity

mTOR inhibition can promote or inhibit immune responses in a context dependent manner, but whether this will represent a net benefit or be contraindicated in the context of immunooncology therapies is less understood. Here, we report that the mTORC1/2 dual kinase inhibitor vistusertib (AZD2014) pote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Langdon, Sophie, Hughes, Adina, Taylor, Molly A., Kuczynski, Elizabeth A., Mele, Deanna A., Delpuech, Oona, Jarvis, Laura, Staniszewska, Anna, Cosulich, Sabina, Carnevalli, Larissa S., Sinclair, Charles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136876/ https://www.ncbi.nlm.nih.gov/pubmed/30221055 http://dx.doi.org/10.1080/2162402X.2018.1458810

Ejemplares similares

PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8(+) T-cell activity
por: Carnevalli, Larissa S., et al.
Publicado: (2018)

Longitudinal tracking of T cell lymphomas in mice using flow cytometry
por: Kuczynski, Elizabeth A., et al.
Publicado: (2023)

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity
por: Wang, Shan, et al.
Publicado: (2020)

A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability
por: Kuczynski, Elizabeth A, et al.
Publicado: (2022)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
por: Ehinger, Yann, et al.
Publicado: (2021)

Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery
por: Taylor, Molly A., et al.
Publicado: (2019)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

mTORC2 confers neuroprotection and potentiates immunity during virus infection
por: Suryawanshi, Rahul K., et al.
Publicado: (2021)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
por: Benavides-Serrato, Angelica, et al.
Publicado: (2017)

Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance
por: Do, Mytrang H., et al.
Publicado: (2019)

Role of mTORC1 Signaling in Regulating the Immune Function of Granulocytes in Teleost Fish
por: Cao, Jiafeng, et al.
Publicado: (2023)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
por: Kuss-Duerkop, Sharon K., et al.
Publicado: (2017)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
por: Benavides-Serrato, Angelica, et al.
Publicado: (2019)

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
por: McCabe, Matthew P, et al.
Publicado: (2020)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

Something to mTORC About in NASH
por: Finck, Brian N.
Publicado: (2022)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections
por: Fang, Lijun, et al.
Publicado: (2016)

mTORC1 couples immune signals and metabolic programming to establish T(reg) cell function
por: Zeng, Hu, et al.
Publicado: (2013)

Regulation of mTORC1 activity by the Golgi apparatus
por: Makhoul, Christian, et al.
Publicado: (2021)

Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
por: Baek, Mi-Ock, et al.
Publicado: (2018)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
por: Cullen, Erin R., et al.
Publicado: (2023)

ER Stress Induces Anabolic Resistance in Muscle Cells through PKB-Induced Blockade of mTORC1
por: Deldicque, Louise, et al.
Publicado: (2011)

Retraction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
Publicado: (2023)

Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis
por: Pollizzi, Kristen, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_92oih2v1j249tdqugaoqhm5hqn