High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the...

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Detalles Bibliográficos
Autores principales: Wierz, Marina, Janji, Bassam, Berchem, Guy, Moussay, Etienne, Paggetti, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136877/
https://www.ncbi.nlm.nih.gov/pubmed/30221064
http://dx.doi.org/10.1080/2162402X.2018.1465167
Descripción
Sumario:In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.

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