High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the...

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Detalles Bibliográficos
Autores principales: Wierz, Marina, Janji, Bassam, Berchem, Guy, Moussay, Etienne, Paggetti, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136877/
https://www.ncbi.nlm.nih.gov/pubmed/30221064
http://dx.doi.org/10.1080/2162402X.2018.1465167
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author Wierz, Marina
Janji, Bassam
Berchem, Guy
Moussay, Etienne
Paggetti, Jerome
author_facet Wierz, Marina
Janji, Bassam
Berchem, Guy
Moussay, Etienne
Paggetti, Jerome
author_sort Wierz, Marina
collection PubMed
description In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.
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spelling pubmed-61368772018-09-14 High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia Wierz, Marina Janji, Bassam Berchem, Guy Moussay, Etienne Paggetti, Jerome Oncoimmunology Author's View In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL. Taylor & Francis 2018-05-24 /pmc/articles/PMC6136877/ /pubmed/30221064 http://dx.doi.org/10.1080/2162402X.2018.1465167 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Wierz, Marina
Janji, Bassam
Berchem, Guy
Moussay, Etienne
Paggetti, Jerome
High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia
title High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia
title_full High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia
title_fullStr High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia
title_full_unstemmed High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia
title_short High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia
title_sort high-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136877/
https://www.ncbi.nlm.nih.gov/pubmed/30221064
http://dx.doi.org/10.1080/2162402X.2018.1465167
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