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Role of Acid Sphingomyelinase and Ceramide in Mechano-Acoustic Enhancement of Tumor Radiation Responses

BACKGROUND: High-dose radiotherapy (>8–10 Gy) causes rapid endothelial cell death via acid sphingomyelinase (ASMase)–induced ceramide production, resulting in biologically significant enhancement of tumor responses. To further augment or solicit similar effects at low radiation doses, we used gen...

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Detalles Bibliográficos
Autores principales:	El Kaffas, Ahmed, Al-Mahrouki, Azza, Hashim, Amr, Law, Niki, Giles, Anoja, Czarnota, Gregory J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136928/ https://www.ncbi.nlm.nih.gov/pubmed/29506145 http://dx.doi.org/10.1093/jnci/djy011

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