The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer

OBJECTIVE: To evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer. METHODS: We retrospectively reviewed the medical records of 309 women with breast cancer who were currently receiving tamoxifen and undergoing regular gynecological examination. RESULTS: We eval...

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Detalles Bibliográficos
Autores principales: Lee, Seul, Kim, Yun Hwa, Kim, Seung Chul, Joo, Jong Kil, Seo, Dong Suh, Kim, Ki Hyung, Lee, Kyu Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137019/
https://www.ncbi.nlm.nih.gov/pubmed/30254998
http://dx.doi.org/10.5468/ogs.2018.61.5.615
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author Lee, Seul
Kim, Yun Hwa
Kim, Seung Chul
Joo, Jong Kil
Seo, Dong Suh
Kim, Ki Hyung
Lee, Kyu Sup
author_facet Lee, Seul
Kim, Yun Hwa
Kim, Seung Chul
Joo, Jong Kil
Seo, Dong Suh
Kim, Ki Hyung
Lee, Kyu Sup
author_sort Lee, Seul
collection PubMed
description OBJECTIVE: To evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer. METHODS: We retrospectively reviewed the medical records of 309 women with breast cancer who were currently receiving tamoxifen and undergoing regular gynecological examination. RESULTS: We evaluated 92 pre- and 217 postmenopausal women. The prevalence of endometrial thickening was 12% in the pre- and 10.6% in the postmenopausal group. An endometrial biopsy was performed in 43 women and confirmed endometrial cancer in 1, endometrial polyps in 14, and endometrial hyperplasia in 4 women. Transvaginal ultrasonography showed 25 cases of newly developed ovarian cysts. Most ovarian cysts had disappeared during follow-up. CONCLUSION: Tamoxifen use in women with breast cancer causes few complications and is considered safe for female reproductive organs in case of regular gynecological examination.
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spelling pubmed-61370192018-09-25 The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer Lee, Seul Kim, Yun Hwa Kim, Seung Chul Joo, Jong Kil Seo, Dong Suh Kim, Ki Hyung Lee, Kyu Sup Obstet Gynecol Sci Original Article OBJECTIVE: To evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer. METHODS: We retrospectively reviewed the medical records of 309 women with breast cancer who were currently receiving tamoxifen and undergoing regular gynecological examination. RESULTS: We evaluated 92 pre- and 217 postmenopausal women. The prevalence of endometrial thickening was 12% in the pre- and 10.6% in the postmenopausal group. An endometrial biopsy was performed in 43 women and confirmed endometrial cancer in 1, endometrial polyps in 14, and endometrial hyperplasia in 4 women. Transvaginal ultrasonography showed 25 cases of newly developed ovarian cysts. Most ovarian cysts had disappeared during follow-up. CONCLUSION: Tamoxifen use in women with breast cancer causes few complications and is considered safe for female reproductive organs in case of regular gynecological examination. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2018-09 2018-08-13 /pmc/articles/PMC6137019/ /pubmed/30254998 http://dx.doi.org/10.5468/ogs.2018.61.5.615 Text en Copyright © 2018 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Seul
Kim, Yun Hwa
Kim, Seung Chul
Joo, Jong Kil
Seo, Dong Suh
Kim, Ki Hyung
Lee, Kyu Sup
The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer
title The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer
title_full The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer
title_fullStr The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer
title_full_unstemmed The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer
title_short The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer
title_sort effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137019/
https://www.ncbi.nlm.nih.gov/pubmed/30254998
http://dx.doi.org/10.5468/ogs.2018.61.5.615
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