γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential

Knowledge of γ-tubulin is increasing with regard to the cellular functions of this protein beyond its participation in microtubule nucleation. γ-Tubulin expression is altered in various malignancies, and changes in the TUBG1 gene have been found in patients suffering from brain malformations. This r...

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Autor principal: Alvarado-Kristensson, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137058/
https://www.ncbi.nlm.nih.gov/pubmed/30221013
http://dx.doi.org/10.1038/s41392-018-0021-x
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author Alvarado-Kristensson, Maria
author_facet Alvarado-Kristensson, Maria
author_sort Alvarado-Kristensson, Maria
collection PubMed
description Knowledge of γ-tubulin is increasing with regard to the cellular functions of this protein beyond its participation in microtubule nucleation. γ-Tubulin expression is altered in various malignancies, and changes in the TUBG1 gene have been found in patients suffering from brain malformations. This review recapitulates the known functions of γ-tubulin in cellular homeostasis and discusses the possible influence of the protein on disease development and cancer.
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spelling pubmed-61370582018-09-14 γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential Alvarado-Kristensson, Maria Signal Transduct Target Ther Review Article Knowledge of γ-tubulin is increasing with regard to the cellular functions of this protein beyond its participation in microtubule nucleation. γ-Tubulin expression is altered in various malignancies, and changes in the TUBG1 gene have been found in patients suffering from brain malformations. This review recapitulates the known functions of γ-tubulin in cellular homeostasis and discusses the possible influence of the protein on disease development and cancer. Nature Publishing Group UK 2018-09-14 /pmc/articles/PMC6137058/ /pubmed/30221013 http://dx.doi.org/10.1038/s41392-018-0021-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Alvarado-Kristensson, Maria
γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential
title γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential
title_full γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential
title_fullStr γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential
title_full_unstemmed γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential
title_short γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential
title_sort γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137058/
https://www.ncbi.nlm.nih.gov/pubmed/30221013
http://dx.doi.org/10.1038/s41392-018-0021-x
work_keys_str_mv AT alvaradokristenssonmaria gtubulinasasignaltransducingmoleculeandmeshworkwiththerapeuticpotential

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