TGFΒ-induced transcription in cancer

The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stage...

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Autores principales: Cantelli, Gaia, Crosas-Molist, Eva, Georgouli, Mirella, Sanz-Moreno, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137079/
https://www.ncbi.nlm.nih.gov/pubmed/27586372
http://dx.doi.org/10.1016/j.semcancer.2016.08.009
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author Cantelli, Gaia
Crosas-Molist, Eva
Georgouli, Mirella
Sanz-Moreno, Victoria
author_facet Cantelli, Gaia
Crosas-Molist, Eva
Georgouli, Mirella
Sanz-Moreno, Victoria
author_sort Cantelli, Gaia
collection PubMed
description The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stages. In this review, we discuss the effects of TGFβ-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFβ target genes are specifically involved in promoting metastasis, we speculate that these genes might be good targets to block tumour progression without compromising the tumour suppressor effects of the TGFβ pathway.
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spelling pubmed-61370792018-09-19 TGFΒ-induced transcription in cancer Cantelli, Gaia Crosas-Molist, Eva Georgouli, Mirella Sanz-Moreno, Victoria Semin Cancer Biol Article The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stages. In this review, we discuss the effects of TGFβ-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFβ target genes are specifically involved in promoting metastasis, we speculate that these genes might be good targets to block tumour progression without compromising the tumour suppressor effects of the TGFβ pathway. Academic Press 2017-02 /pmc/articles/PMC6137079/ /pubmed/27586372 http://dx.doi.org/10.1016/j.semcancer.2016.08.009 Text en © 2016 Elsevier Ltd. All rights reserved. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cantelli, Gaia
Crosas-Molist, Eva
Georgouli, Mirella
Sanz-Moreno, Victoria
TGFΒ-induced transcription in cancer
title TGFΒ-induced transcription in cancer
title_full TGFΒ-induced transcription in cancer
title_fullStr TGFΒ-induced transcription in cancer
title_full_unstemmed TGFΒ-induced transcription in cancer
title_short TGFΒ-induced transcription in cancer
title_sort tgfβ-induced transcription in cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137079/
https://www.ncbi.nlm.nih.gov/pubmed/27586372
http://dx.doi.org/10.1016/j.semcancer.2016.08.009
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