Advanced glycation end products accelerate calcification in VSMCs through HIF-1α/PDK4 activation and suppress glucose metabolism

Arterial media calcification is associated with diabetes mellitus. Previous studies have shown that advanced glycation end products (AGEs) are responsible for vascular smooth muscle cell (VSMC) calcification, but the underlying mechanisms remain unclear. Hypoxia-inducible factor-1α (HIF-1α), one of...

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Detalles Bibliográficos
Autores principales: Zhu, Yi, Ma, Wen-Qi, Han, Xi-Qiong, Wang, Ying, Wang, Xin, Liu, Nai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137084/
https://www.ncbi.nlm.nih.gov/pubmed/30213959
http://dx.doi.org/10.1038/s41598-018-31877-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137084/
https://www.ncbi.nlm.nih.gov/pubmed/30213959
http://dx.doi.org/10.1038/s41598-018-31877-6

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