Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities

Dysregulation of repressor-element 1 silencing transcription factor REST/NRSF is related to several neuropathies, including medulloblastoma, glioblastoma, Huntington’s disease, and neuropathic pain. Inhibitors of the interaction between the N-terminal repressor domain of REST/NRSF and the PAH1 domai...

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Detalles Bibliográficos
Autores principales: Kurita, Jun-ichi, Hirao, Yuuka, Nakano, Hirofumi, Fukunishi, Yoshifumi, Nishimura, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137095/
https://www.ncbi.nlm.nih.gov/pubmed/30213984
http://dx.doi.org/10.1038/s41598-018-31852-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137095/
https://www.ncbi.nlm.nih.gov/pubmed/30213984
http://dx.doi.org/10.1038/s41598-018-31852-1

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