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Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95

Previous studies of the N-terminal PDZ tandem from PSD-95 produced divergent models and failed to identify interdomain contacts stabilizing the structure. We used ensemble and single-molecule FRET along with replica-exchange molecular dynamics to fully characterize the energy landscape. Simulations...

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Detalles Bibliográficos
Autores principales:	Yanez Orozco, Inna S., Mindlin, Frank A., Ma, Junyan, Wang, Bo, Levesque, Brie, Spencer, Matheu, Rezaei Adariani, Soheila, Hamilton, George, Ding, Feng, Bowen, Mark E., Sanabria, Hugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137104/ https://www.ncbi.nlm.nih.gov/pubmed/30214057 http://dx.doi.org/10.1038/s41467-018-06133-0

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