Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial

BACKGROUND: Acute kidney injury independently predicts mortality in falciparum malaria. It is unknown whether acetaminophen’s capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria. METHODS: This phase 2, open-label, randomized controlled trial conducted at two...

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Detalles Bibliográficos
Autores principales: Plewes, Katherine, Kingston, Hugh W F, Ghose, Aniruddha, Wattanakul, Thanaporn, Hassan, Md Mahtab Uddin, Haider, Md Shafiul, Dutta, Prodip K, Islam, Md Akhterul, Alam, Shamsul, Jahangir, Selim Md, Zahed, A S M, Sattar, Md Abdus, Chowdhury, M A Hassan, Herdman, M Trent, Leopold, Stije J, Ishioka, Haruhiko, Piera, Kim A, Charunwatthana, Prakaykaew, Silamut, Kamolrat, Yeo, Tsin W, Lee, Sue J, Mukaka, Mavuto, Maude, Richard J, Turner, Gareth D H, Faiz, Md Abul, Tarning, Joel, Oates, John A, Anstey, Nicholas M, White, Nicholas J, Day, Nicholas P J, Hossain, Md Amir, Roberts II, L Jackson, Dondorp, Arjen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Articles and Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137116/
https://www.ncbi.nlm.nih.gov/pubmed/29538635
http://dx.doi.org/10.1093/cid/ciy213

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