MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice

Animal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual...

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Autores principales: Bello-Arroyo, Elísabet, Roque, Hélio, Marcos, Alberto, Orihuel, Javier, Higuera-Matas, Alejandro, Desco, Manuel, Caiolfa, Valeria R., Ambrosio, Emilio, Lara-Pezzi, Enrique, Gómez-Gaviro, María Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137138/
https://www.ncbi.nlm.nih.gov/pubmed/30245618
http://dx.doi.org/10.3389/fnbeh.2018.00201
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author Bello-Arroyo, Elísabet
Roque, Hélio
Marcos, Alberto
Orihuel, Javier
Higuera-Matas, Alejandro
Desco, Manuel
Caiolfa, Valeria R.
Ambrosio, Emilio
Lara-Pezzi, Enrique
Gómez-Gaviro, María Victoria
author_facet Bello-Arroyo, Elísabet
Roque, Hélio
Marcos, Alberto
Orihuel, Javier
Higuera-Matas, Alejandro
Desco, Manuel
Caiolfa, Valeria R.
Ambrosio, Emilio
Lara-Pezzi, Enrique
Gómez-Gaviro, María Victoria
author_sort Bello-Arroyo, Elísabet
collection PubMed
description Animal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically. These tests include Open Field (OF), Elevated Plus Maze (EPM), Y-maze (YM) test and Morris Water Maze (MWM). MouBeAT showed a high correlation with manual evaluation in all the parameters analyzed for all the behavioral tests, reinforcing its value as an accurate analysis tool. This new tool is freely available online.
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spelling pubmed-61371382018-09-21 MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice Bello-Arroyo, Elísabet Roque, Hélio Marcos, Alberto Orihuel, Javier Higuera-Matas, Alejandro Desco, Manuel Caiolfa, Valeria R. Ambrosio, Emilio Lara-Pezzi, Enrique Gómez-Gaviro, María Victoria Front Behav Neurosci Neuroscience Animal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically. These tests include Open Field (OF), Elevated Plus Maze (EPM), Y-maze (YM) test and Morris Water Maze (MWM). MouBeAT showed a high correlation with manual evaluation in all the parameters analyzed for all the behavioral tests, reinforcing its value as an accurate analysis tool. This new tool is freely available online. Frontiers Media S.A. 2018-09-07 /pmc/articles/PMC6137138/ /pubmed/30245618 http://dx.doi.org/10.3389/fnbeh.2018.00201 Text en Copyright © 2018 Bello-Arroyo, Roque, Marcos, Orihuel, Higuera-Matas, Desco, Caiolfa, Ambrosio, Lara-Pezzi and Gómez-Gaviro. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bello-Arroyo, Elísabet
Roque, Hélio
Marcos, Alberto
Orihuel, Javier
Higuera-Matas, Alejandro
Desco, Manuel
Caiolfa, Valeria R.
Ambrosio, Emilio
Lara-Pezzi, Enrique
Gómez-Gaviro, María Victoria
MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice
title MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice
title_full MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice
title_fullStr MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice
title_full_unstemmed MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice
title_short MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice
title_sort moubeat: a new and open toolbox for guided analysis of behavioral tests in mice
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137138/
https://www.ncbi.nlm.nih.gov/pubmed/30245618
http://dx.doi.org/10.3389/fnbeh.2018.00201
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