Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach

Post-transcriptional processes have been recognised as pivotal in the control of gene expression, and impairments in RNA processing are reported in several pathologies (i.e., cancer and neurodegeneration). Focusing on RNA-binding proteins (RBPs), the involvement of Embryonic Lethal Abnormal Vision (...

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Detalles Bibliográficos
Autores principales: Vasile, Francesca, Della Volpe, Serena, Ambrosio, Francesca Alessandra, Costa, Giosuè, Unver, M. Yagiz, Zucal, Chiara, Rossi, Daniela, Martino, Emanuela, Provenzani, Alessandro, Hirsch, Anna K. H., Alcaro, Stefano, Potenza, Donatella, Collina, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137155/
https://www.ncbi.nlm.nih.gov/pubmed/30214075
http://dx.doi.org/10.1038/s41598-018-32084-z

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