Cargando…
Etoposide-resistance in a neuroblastoma model cell line is associated with 13q14.3 mono-allelic deletion and miRNA-15a/16-1 down-regulation
Drug resistance is the major obstacle in successfully treating high-risk neuroblastoma. The aim of this study was to investigate the basis of etoposide-resistance in neuroblastoma. To this end, a MYCN-amplified neuroblastoma cell line (HTLA-230) was treated with increasing etoposide concentrations a...
Autores principales: | Marengo, Barbara, Monti, Paola, Miele, Mariangela, Menichini, Paola, Ottaggio, Laura, Foggetti, Giorgia, Pulliero, Alessandra, Izzotti, Alberto, Speciale, Andrea, Garbarino, Ombretta, Traverso, Nicola, Fronza, Gilberto, Domenicotti, Cinzia |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137223/ https://www.ncbi.nlm.nih.gov/pubmed/30213983 http://dx.doi.org/10.1038/s41598-018-32195-7 |
Ejemplares similares
-
Potential Role of miRNAs in the Acquisition of Chemoresistance in Neuroblastoma
por: Marengo, Barbara, et al.
Publicado: (2021) -
Autophagy induced by SAHA affects mutant P53 degradation and cancer cell survival
por: Foggetti, Giorgia, et al.
Publicado: (2019) -
TP63 mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear
por: Monti, Paola, et al.
Publicado: (2017) -
PKCα Inhibition as a Strategy to Sensitize Neuroblastoma Stem Cells to Etoposide by Stimulating Ferroptosis
por: Monteleone, Lorenzo, et al.
Publicado: (2021) -
Mutant p53(K120R) expression enables a partial capacity to modulate metabolism
por: Monti, Paola, et al.
Publicado: (2022)