Cargando…

DNA hypermethylation and differential gene expression associated with Klinefelter syndrome

Klinefelter syndrome (KS) has a prevalence ranging from 85 to 250 per 100.000 newborn boys making it the most frequent sex chromosome aneuploidy in the general population. The molecular basis for the phenotypic traits and morbidity in KS are not clarified. We performed genome-wide DNA methylation pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Skakkebæk, Anne, Nielsen, Morten Muhlig, Trolle, Christian, Vang, Søren, Hornshøj, Henrik, Hedegaard, Jakob, Wallentin, Mikkel, Bojesen, Anders, Hertz, Jens Michael, Fedder, Jens, Østergaard, John Rosendahl, Pedersen, Jakob Skou, Gravholt, Claus Højbjerg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137224/ https://www.ncbi.nlm.nih.gov/pubmed/30213969 http://dx.doi.org/10.1038/s41598-018-31780-0

Ejemplares similares

Neuroanatomical correlates of Klinefelter syndrome studied in relation to the neuropsychological profile()
por: Skakkebæk, Anne, et al.
Publicado: (2013)

Klinefelter syndrome has increased brain responses to auditory stimuli and motor output, but not to visual stimuli or Stroop adaptation
por: Wallentin, Mikkel, et al.
Publicado: (2016)

The role of genes, intelligence, personality, and social engagement in cognitive performance in Klinefelter syndrome
por: Skakkebæk, Anne, et al.
Publicado: (2017)

Anxiety and depression in Klinefelter syndrome: The impact of personality and social engagement
por: Skakkebæk, Anne, et al.
Publicado: (2018)

Corrigendum to “Neuroanatomical correlates of Klinefelter syndrome studied in relation to the neuropsychological profile” [NeuroImage:Clin 4 (2014) 1–9]
por: Skakkebæk, Anne, et al.
Publicado: (2016)

Widespread DNA hypomethylation and differential gene expression in Turner syndrome
por: Trolle, Christian, et al.
Publicado: (2016)

Criminality in men with Klinefelter's syndrome and XYY syndrome: a cohort study
por: Stochholm, Kirstine, et al.
Publicado: (2012)

Reduced fibrin clot lysis in Klinefelter syndrome associated with hypogonadism
por: Chang, Simon, et al.
Publicado: (2022)

The testicular microvasculature in Klinefelter syndrome is immature with compromised integrity and characterized by excessive inflammatory cross-talk
por: Johannsen, Emma B, et al.
Publicado: (2023)

SAT-046 Insulin-Like Growth Factor and Fibroblast Growth Factor 21 in Men with Klinefelter Syndrome
por: Chang, Simon, et al.
Publicado: (2020)

Identification of expressed and conserved human noncoding RNAs
por: Nielsen, Morten Muhlig, et al.
Publicado: (2014)

Sex chromosome aneuploidies give rise to changes in the circular RNA profile: A circular transcriptome-wide study of Turner and Klinefelter syndrome across different tissues
por: Johannsen, Emma B., et al.
Publicado: (2022)

Changes in the cohort composition of turner syndrome and severe non-diagnosis of Klinefelter, 47,XXX and 47,XYY syndrome: a nationwide cohort study
por: Berglund, Agnethe, et al.
Publicado: (2019)

The role of hypogonadism in Klinefelter Syndrome
por: Høst, Christian, et al.
Publicado: (2014)

A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data
por: Bertl, Johanna, et al.
Publicado: (2018)

Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer
por: Okholm, Trine Line Hauge, et al.
Publicado: (2017)

miRNA activity inferred from single cell mRNA expression
por: Nielsen, Morten Muhlig, et al.
Publicado: (2021)

Evaluation of the Efficacy of Transdermal and Injection Testosterone Therapy in Klinefelter Syndrome: A Real-Life Study
por: Kabilan, Apiraa, et al.
Publicado: (2021)

Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate
por: Juul, Malene, et al.
Publicado: (2017)

Regmex: a statistical tool for exploring motifs in ranked sequence lists from genomics experiments
por: Nielsen, Morten Muhlig, et al.
Publicado: (2018)

Klinefelter syndrome and testosterone treatment: a national cohort study on thrombosis risk
por: Chang, Simon, et al.
Publicado: (2019)

The landscape and driver potential of site-specific hotspots across cancer genomes
por: Juul, Randi Istrup, et al.
Publicado: (2021)

Prolonged QT interval and cardiac arrest after a single dose of amiodarone in a woman with Turner's syndrome
por: Nielsen, Dorte Guldbrand, et al.
Publicado: (2017)

Sequence dependencies and mutation rates of localized mutational processes in cancer
por: Poulsgaard, Gustav Alexander, et al.
Publicado: (2023)

Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival
por: Hornshøj, Henrik, et al.
Publicado: (2018)

A placebo-controlled randomized study with testosterone in Klinefelter syndrome: beneficial effects on body composition
por: Høst, Christian, et al.
Publicado: (2019)

Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types
por: Rasmussen, Martin Q., et al.
Publicado: (2023)

The macrophage low-grade inflammation marker sCD163 is modulated by exogenous sex steroids
por: Thomsen, Henrik H, et al.
Publicado: (2013)

RHCG and TCAF1 promoter hypermethylation predicts biochemical recurrence in prostate cancer patients treated by radical prostatectomy
por: Strand, Siri H., et al.
Publicado: (2016)

Subjective versus objective sleep in men with Klinefelter syndrome
por: Fjermestad, K. W., et al.
Publicado: (2023)

Epigenetic and transcriptomic alterations in offspring born to women with type 1 diabetes (the EPICOM study)
por: Knorr, Sine, et al.
Publicado: (2022)

New developments and future trajectories in supernumerary sex chromosome abnormalities: a summary of the 2022 3rd International Workshop on Klinefelter Syndrome, Trisomy X, and XYY
por: Gravholt, Claus H, et al.
Publicado: (2023)

circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA
por: Okholm, Trine Line Hauge, et al.
Publicado: (2023)

Significance evaluation in factor graphs
por: Madsen, Tobias, et al.
Publicado: (2017)

Morbidity, mortality, and socioeconomics in Klinefelter syndrome and 47,XYY syndrome: a comparative review
por: Ridder, Lukas Ochsner, et al.
Publicado: (2023)

Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells
por: Winge, Sofia Boeg, et al.
Publicado: (2018)

Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression
por: Okholm, Trine Line Hauge, et al.
Publicado: (2020)

Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity
por: Belling, Kirstine, et al.
Publicado: (2017)

Optimized targeted sequencing of cell-free plasma DNA from bladder cancer patients
por: Christensen, Emil, et al.
Publicado: (2018)

Microarray Expression Profiles of 20.000 Genes across 23 Healthy Porcine Tissues
por: Hornshøj, Henrik, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_qrbivtk7f5gjmajpt1qllpvi7t