Cargando…
Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis
Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning (SSN), a traditional Chinese medicine formulation, has been used commonly in China to retard kidney disease progression and decrease uremic toxins in chronic kidney diseas...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137246/ https://www.ncbi.nlm.nih.gov/pubmed/29921575 http://dx.doi.org/10.1042/BSR20171694 |
_version_ | 1783355149404602368 |
---|---|
author | Chen, Xujiao Gao, Shouhong Ruan, Mengna Chen, Sixiu Xu, Jing Xing, Xiaohong Pan, Xiaohong Mei, Changlin Mao, Zhiguo |
author_facet | Chen, Xujiao Gao, Shouhong Ruan, Mengna Chen, Sixiu Xu, Jing Xing, Xiaohong Pan, Xiaohong Mei, Changlin Mao, Zhiguo |
author_sort | Chen, Xujiao |
collection | PubMed |
description | Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning (SSN), a traditional Chinese medicine formulation, has been used commonly in China to retard kidney disease progression and decrease uremic toxins in chronic kidney disease (CKD) patients, but the effects of SSN on serum PBUTs in dialysis patients were not investigated. We conducted a randomized controlled trial in patients on peritoneal dialysis (PD) at dialysis center of Changzheng Hospital to evaluate the effects of SSN on serum PBUTs. Participants with SSN intervention took 5 g SSN granule three times daily for 12 weeks, while the baseline medications and dialysis prescriptions remained during the study in all patients. The serum concentrations of indoxyl sulphate (IS) and p-cresol sulphate (PCS) were determined by HPLC/MS/MS and biochemical parameters were assessed during the study. Sixty PD patients were enrolled and randomly allocated into SSN group and control group. Total IS level was significantly lower in SSN group than in control group at week 4, 8, and 12 (27.28 ± 18.19, 29.73 ± 19.10, and 29.41 ± 17.61 mg/l compared with 39.25 ± 20.23, 44.86 ± 23.91, and 45.34 ± 33.52 mg/l, respectively). However, there were no statistical difference of total PCS, free forms of IS and PCS concentrations between SSN group and control group during 12 weeks follow-up. Administration of SSN granule orally decreased serum total IS level effectively in uremic patients on PD with good tolerance. Benefits of PD patients’ outcomes from IS reduction by SSN awaits further large size and long duration clinical trials to verify. |
format | Online Article Text |
id | pubmed-6137246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61372462018-09-18 Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis Chen, Xujiao Gao, Shouhong Ruan, Mengna Chen, Sixiu Xu, Jing Xing, Xiaohong Pan, Xiaohong Mei, Changlin Mao, Zhiguo Biosci Rep Research Articles Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning (SSN), a traditional Chinese medicine formulation, has been used commonly in China to retard kidney disease progression and decrease uremic toxins in chronic kidney disease (CKD) patients, but the effects of SSN on serum PBUTs in dialysis patients were not investigated. We conducted a randomized controlled trial in patients on peritoneal dialysis (PD) at dialysis center of Changzheng Hospital to evaluate the effects of SSN on serum PBUTs. Participants with SSN intervention took 5 g SSN granule three times daily for 12 weeks, while the baseline medications and dialysis prescriptions remained during the study in all patients. The serum concentrations of indoxyl sulphate (IS) and p-cresol sulphate (PCS) were determined by HPLC/MS/MS and biochemical parameters were assessed during the study. Sixty PD patients were enrolled and randomly allocated into SSN group and control group. Total IS level was significantly lower in SSN group than in control group at week 4, 8, and 12 (27.28 ± 18.19, 29.73 ± 19.10, and 29.41 ± 17.61 mg/l compared with 39.25 ± 20.23, 44.86 ± 23.91, and 45.34 ± 33.52 mg/l, respectively). However, there were no statistical difference of total PCS, free forms of IS and PCS concentrations between SSN group and control group during 12 weeks follow-up. Administration of SSN granule orally decreased serum total IS level effectively in uremic patients on PD with good tolerance. Benefits of PD patients’ outcomes from IS reduction by SSN awaits further large size and long duration clinical trials to verify. Portland Press Ltd. 2018-09-14 /pmc/articles/PMC6137246/ /pubmed/29921575 http://dx.doi.org/10.1042/BSR20171694 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Chen, Xujiao Gao, Shouhong Ruan, Mengna Chen, Sixiu Xu, Jing Xing, Xiaohong Pan, Xiaohong Mei, Changlin Mao, Zhiguo Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis |
title | Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis |
title_full | Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis |
title_fullStr | Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis |
title_full_unstemmed | Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis |
title_short | Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis |
title_sort | shen-shuai-ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137246/ https://www.ncbi.nlm.nih.gov/pubmed/29921575 http://dx.doi.org/10.1042/BSR20171694 |
work_keys_str_mv | AT chenxujiao shenshuaininggranuledecreasedserumconcentrationsofindoxylsulphateinuremicpatientsundergoingperitonealdialysis AT gaoshouhong shenshuaininggranuledecreasedserumconcentrationsofindoxylsulphateinuremicpatientsundergoingperitonealdialysis AT ruanmengna shenshuaininggranuledecreasedserumconcentrationsofindoxylsulphateinuremicpatientsundergoingperitonealdialysis AT chensixiu shenshuaininggranuledecreasedserumconcentrationsofindoxylsulphateinuremicpatientsundergoingperitonealdialysis AT xujing shenshuaininggranuledecreasedserumconcentrationsofindoxylsulphateinuremicpatientsundergoingperitonealdialysis AT xingxiaohong shenshuaininggranuledecreasedserumconcentrationsofindoxylsulphateinuremicpatientsundergoingperitonealdialysis AT panxiaohong shenshuaininggranuledecreasedserumconcentrationsofindoxylsulphateinuremicpatientsundergoingperitonealdialysis AT meichanglin shenshuaininggranuledecreasedserumconcentrationsofindoxylsulphateinuremicpatientsundergoingperitonealdialysis AT maozhiguo shenshuaininggranuledecreasedserumconcentrationsofindoxylsulphateinuremicpatientsundergoingperitonealdialysis |