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Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility

Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case–control studies have been conducted to assess the association of IL-6 -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive...

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Autores principales: Duan, Hai-Xia, Chen, You-Yi, Shi, Juan-Zi, Ren, Nan-Nan, Li, Xiao-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137247/
https://www.ncbi.nlm.nih.gov/pubmed/30135142
http://dx.doi.org/10.1042/BSR20181071
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author Duan, Hai-Xia
Chen, You-Yi
Shi, Juan-Zi
Ren, Nan-Nan
Li, Xiao-Juan
author_facet Duan, Hai-Xia
Chen, You-Yi
Shi, Juan-Zi
Ren, Nan-Nan
Li, Xiao-Juan
author_sort Duan, Hai-Xia
collection PubMed
description Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case–control studies have been conducted to assess the association of IL-6 -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive a more precise estimation of the relationship, we performed this meta-analysis updated to June 2018. A total of seven original publications were identified covering IL-6 -174G>C (rs1800795) polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship strengths. Statistically significant relationship was observed between IL-6 -174G>C polymorphism and cervical cancer risk (OR = 0.61, 95% CI: 0.40–0.94 for GG vs. CC, and OR = 0.77, 95% CI: 0.64–0.93 for G vs. C). Moreover, the significant association was found among Asians (OR = 0.46, 95% CI: 0.29–0.75 for GG vs. CC, and OR = 0.70, 95% CI: 0.57–0.89 for G vs. C); hospital-based subgroup (OR = 0.53, 95% CI: 0.38–0.72 for GG vs. CC, and OR = 0.73, 95% CI: 0.61–0.87 for G vs. C); and Hardy–Weinberg equilibrium ≤0.05 (OR = 0.56, 95% CI: 0.37–0.86 for GG vs. GC, and OR = 0.66, 95% CI: 0.47–0.93 for G vs. C). This meta-analysis showed the evidence that the IL-6 -174G>C polymorphism was a low-penetrance susceptibility variant for cervical cancer. Further large-scale case–control studies are needed to confirm these results.
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spelling pubmed-61372472018-09-18 Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility Duan, Hai-Xia Chen, You-Yi Shi, Juan-Zi Ren, Nan-Nan Li, Xiao-Juan Biosci Rep Research Articles Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case–control studies have been conducted to assess the association of IL-6 -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive a more precise estimation of the relationship, we performed this meta-analysis updated to June 2018. A total of seven original publications were identified covering IL-6 -174G>C (rs1800795) polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship strengths. Statistically significant relationship was observed between IL-6 -174G>C polymorphism and cervical cancer risk (OR = 0.61, 95% CI: 0.40–0.94 for GG vs. CC, and OR = 0.77, 95% CI: 0.64–0.93 for G vs. C). Moreover, the significant association was found among Asians (OR = 0.46, 95% CI: 0.29–0.75 for GG vs. CC, and OR = 0.70, 95% CI: 0.57–0.89 for G vs. C); hospital-based subgroup (OR = 0.53, 95% CI: 0.38–0.72 for GG vs. CC, and OR = 0.73, 95% CI: 0.61–0.87 for G vs. C); and Hardy–Weinberg equilibrium ≤0.05 (OR = 0.56, 95% CI: 0.37–0.86 for GG vs. GC, and OR = 0.66, 95% CI: 0.47–0.93 for G vs. C). This meta-analysis showed the evidence that the IL-6 -174G>C polymorphism was a low-penetrance susceptibility variant for cervical cancer. Further large-scale case–control studies are needed to confirm these results. Portland Press Ltd. 2018-09-14 /pmc/articles/PMC6137247/ /pubmed/30135142 http://dx.doi.org/10.1042/BSR20181071 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Duan, Hai-Xia
Chen, You-Yi
Shi, Juan-Zi
Ren, Nan-Nan
Li, Xiao-Juan
Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility
title Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility
title_full Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility
title_fullStr Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility
title_full_unstemmed Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility
title_short Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility
title_sort association of il-6 -174g>c (rs1800795) polymorphism with cervical cancer susceptibility
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137247/
https://www.ncbi.nlm.nih.gov/pubmed/30135142
http://dx.doi.org/10.1042/BSR20181071
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