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Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility
Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case–control studies have been conducted to assess the association of IL-6 -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137247/ https://www.ncbi.nlm.nih.gov/pubmed/30135142 http://dx.doi.org/10.1042/BSR20181071 |
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author | Duan, Hai-Xia Chen, You-Yi Shi, Juan-Zi Ren, Nan-Nan Li, Xiao-Juan |
author_facet | Duan, Hai-Xia Chen, You-Yi Shi, Juan-Zi Ren, Nan-Nan Li, Xiao-Juan |
author_sort | Duan, Hai-Xia |
collection | PubMed |
description | Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case–control studies have been conducted to assess the association of IL-6 -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive a more precise estimation of the relationship, we performed this meta-analysis updated to June 2018. A total of seven original publications were identified covering IL-6 -174G>C (rs1800795) polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship strengths. Statistically significant relationship was observed between IL-6 -174G>C polymorphism and cervical cancer risk (OR = 0.61, 95% CI: 0.40–0.94 for GG vs. CC, and OR = 0.77, 95% CI: 0.64–0.93 for G vs. C). Moreover, the significant association was found among Asians (OR = 0.46, 95% CI: 0.29–0.75 for GG vs. CC, and OR = 0.70, 95% CI: 0.57–0.89 for G vs. C); hospital-based subgroup (OR = 0.53, 95% CI: 0.38–0.72 for GG vs. CC, and OR = 0.73, 95% CI: 0.61–0.87 for G vs. C); and Hardy–Weinberg equilibrium ≤0.05 (OR = 0.56, 95% CI: 0.37–0.86 for GG vs. GC, and OR = 0.66, 95% CI: 0.47–0.93 for G vs. C). This meta-analysis showed the evidence that the IL-6 -174G>C polymorphism was a low-penetrance susceptibility variant for cervical cancer. Further large-scale case–control studies are needed to confirm these results. |
format | Online Article Text |
id | pubmed-6137247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61372472018-09-18 Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility Duan, Hai-Xia Chen, You-Yi Shi, Juan-Zi Ren, Nan-Nan Li, Xiao-Juan Biosci Rep Research Articles Interleukin-6 (IL-6) is a multifunctional cytokine that has been implicated in the etiology of cancer. Several case–control studies have been conducted to assess the association of IL-6 -174G>C (rs1800795) polymorphism with the risk of cervical cancer, yet with conflicting conclusions. To derive a more precise estimation of the relationship, we performed this meta-analysis updated to June 2018. A total of seven original publications were identified covering IL-6 -174G>C (rs1800795) polymorphism. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the relationship strengths. Statistically significant relationship was observed between IL-6 -174G>C polymorphism and cervical cancer risk (OR = 0.61, 95% CI: 0.40–0.94 for GG vs. CC, and OR = 0.77, 95% CI: 0.64–0.93 for G vs. C). Moreover, the significant association was found among Asians (OR = 0.46, 95% CI: 0.29–0.75 for GG vs. CC, and OR = 0.70, 95% CI: 0.57–0.89 for G vs. C); hospital-based subgroup (OR = 0.53, 95% CI: 0.38–0.72 for GG vs. CC, and OR = 0.73, 95% CI: 0.61–0.87 for G vs. C); and Hardy–Weinberg equilibrium ≤0.05 (OR = 0.56, 95% CI: 0.37–0.86 for GG vs. GC, and OR = 0.66, 95% CI: 0.47–0.93 for G vs. C). This meta-analysis showed the evidence that the IL-6 -174G>C polymorphism was a low-penetrance susceptibility variant for cervical cancer. Further large-scale case–control studies are needed to confirm these results. Portland Press Ltd. 2018-09-14 /pmc/articles/PMC6137247/ /pubmed/30135142 http://dx.doi.org/10.1042/BSR20181071 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Duan, Hai-Xia Chen, You-Yi Shi, Juan-Zi Ren, Nan-Nan Li, Xiao-Juan Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility |
title | Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility |
title_full | Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility |
title_fullStr | Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility |
title_full_unstemmed | Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility |
title_short | Association of IL-6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility |
title_sort | association of il-6 -174g>c (rs1800795) polymorphism with cervical cancer susceptibility |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137247/ https://www.ncbi.nlm.nih.gov/pubmed/30135142 http://dx.doi.org/10.1042/BSR20181071 |
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