1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology

1-Aminobenzotriazole (1-ABT) is a pan-specific, mechanism-based inactivator of the xenobiotic metabolizing forms of cytochrome P450 in animals, plants, insects, and microorganisms. It has been widely used to investigate the biological roles of cytochrome P450 enzymes, their participation in the meta...

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Autor principal: de Montellano, Paul R Ortiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137267/
https://www.ncbi.nlm.nih.gov/pubmed/30221034
http://dx.doi.org/10.4172/2161-0444.1000495
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author de Montellano, Paul R Ortiz
author_facet de Montellano, Paul R Ortiz
author_sort de Montellano, Paul R Ortiz
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description 1-Aminobenzotriazole (1-ABT) is a pan-specific, mechanism-based inactivator of the xenobiotic metabolizing forms of cytochrome P450 in animals, plants, insects, and microorganisms. It has been widely used to investigate the biological roles of cytochrome P450 enzymes, their participation in the metabolism of both endobiotics and xenobiotics, and their contributions to the metabolism-dependent toxicity of drugs and chemicals. This review is a comprehensive evaluation of the chemistry, discovery, and use of 1-aminobenzotriazole in these contexts from its introduction in 1981 to the present.
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spelling pubmed-61372672018-09-14 1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology de Montellano, Paul R Ortiz Med Chem (Los Angeles) Article 1-Aminobenzotriazole (1-ABT) is a pan-specific, mechanism-based inactivator of the xenobiotic metabolizing forms of cytochrome P450 in animals, plants, insects, and microorganisms. It has been widely used to investigate the biological roles of cytochrome P450 enzymes, their participation in the metabolism of both endobiotics and xenobiotics, and their contributions to the metabolism-dependent toxicity of drugs and chemicals. This review is a comprehensive evaluation of the chemistry, discovery, and use of 1-aminobenzotriazole in these contexts from its introduction in 1981 to the present. 2018-03-31 2018 /pmc/articles/PMC6137267/ /pubmed/30221034 http://dx.doi.org/10.4172/2161-0444.1000495 Text en This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited http://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Article
de Montellano, Paul R Ortiz
1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
title 1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
title_full 1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
title_fullStr 1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
title_full_unstemmed 1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
title_short 1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
title_sort 1-aminobenzotriazole: a mechanism-based cytochrome p450 inhibitor and probe of cytochrome p450 biology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137267/
https://www.ncbi.nlm.nih.gov/pubmed/30221034
http://dx.doi.org/10.4172/2161-0444.1000495
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