Cargando…
Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis
There are significant ambiguities regarding how DNA polymerase η is recruited to DNA lesion sites in stressed cells while avoiding normal replication forks in non-stressed cells. Even less is known about the mechanisms responsible for Pol η-induced mutations in cancer genomes. We show that there are...
Autores principales: | Peddu, Chandana, Zhang, Sufang, Zhao, Hong, Wong, Agnes, Lee, Ernest Y.C., Lee, Marietta Y.W.T., Zhang, Zhongtao |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137289/ https://www.ncbi.nlm.nih.gov/pubmed/30240625 http://dx.doi.org/10.1016/j.isci.2018.07.009 |
Ejemplares similares
-
Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21(WAF1), Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry
por: Darzynkiewicz, Zbigniew, et al.
Publicado: (2015) -
Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties
por: Mishra, Bhanvi, et al.
Publicado: (2018) -
DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis
por: Bergoglio, Valérie, et al.
Publicado: (2013) -
Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
por: Ma, Xiaolu, et al.
Publicado: (2017) -
Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts
por: Schmutz, Valérie, et al.
Publicado: (2010)