Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the Mitochondrial Pyruvate Carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferati...

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Detalles Bibliográficos
Autores principales: Schell, John C., Wisidagama, Dona R., Bensard, Claire, Zhao, Helong, Wei, Peng, Tanner, Jason, Flores, Aimee, Mohlman, Jeffrey, Sorensen, Lise K., Earl, Christian S., Olson, Kristofor A., Miao, Ren, Waller, T. Cameron, Delker, Don, Kanth, Priyanka, Jiang, Lei, DeBerardinis, Ralph J., Bronner, Mary P., Li, Dean Y., Cox, James E., Christofk, Heather R., Lowry, William E., Thummel, Carl S., Rutter, Jared
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137334/
https://www.ncbi.nlm.nih.gov/pubmed/28812582
http://dx.doi.org/10.1038/ncb3593

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