Uncoupling DISC1 × D2R Protein-Protein Interactions Facilitates Latent Inhibition in Disc1-L100P Animal Model of Schizophrenia and Enhances Synaptic Plasticity via D2 Receptors

Both Disrupted-In-Schizophrenia-1 (DISC1) and dopamine receptors D2R have significant contributions to the pathogenesis of schizophrenia. Our previous study demonstrated that DISC1 binds to D2R and such protein-protein interaction is enhanced in patients with schizophrenia and Disc1-L100P mouse mode...

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Detalles Bibliográficos
Autores principales: Lipina, Tatiana V., Beregovoy, Nikolay A., Tkachenko, Alina A., Petrova, Ekaterina S., Starostina, Marina V., Zhou, Qiang, Li, Shupeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137395/
https://www.ncbi.nlm.nih.gov/pubmed/30245624
http://dx.doi.org/10.3389/fnsyn.2018.00031

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