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Comparison of Best Medical Management with Carotid Intervention Procedures in the Prevention of Stroke Recurrence in Patients with Symptomatic Internal Carotid Artery Stenosis
BACKGROUND: As per the current recommendations, carotid interventional procedures (carotid endarterectomy/carotid artery stenting) are considered superior to medical management in reducing the stroke recurrence in patients with symptomatic extracranial internal carotid artery (ICA) stenosis. OBJECTI...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137635/ https://www.ncbi.nlm.nih.gov/pubmed/30258258 http://dx.doi.org/10.4103/aian.AIAN_124_18 |
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author | Deepa Rani, BV Gampa, Sandeep Sirineni, Deepika Harshavardhana, K. R. Krishna, Satya Rama Kaul, Subhash |
author_facet | Deepa Rani, BV Gampa, Sandeep Sirineni, Deepika Harshavardhana, K. R. Krishna, Satya Rama Kaul, Subhash |
author_sort | Deepa Rani, BV |
collection | PubMed |
description | BACKGROUND: As per the current recommendations, carotid interventional procedures (carotid endarterectomy/carotid artery stenting) are considered superior to medical management in reducing the stroke recurrence in patients with symptomatic extracranial internal carotid artery (ICA) stenosis. OBJECTIVE: The objective of this study is to compare the best medical management with carotid interventional procedures in the prevention of stroke recurrence in the patients with symptomatic extracranial ICA stenosis. MATERIALS AND METHODS: This was a parallel, prospective, two-arm, open-label, observational study. Participants were selected consecutively and prospectively among patients from Outpatient and Inpatient Departments of Neurology at Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India. The study period was from January 2012 to December 2017. RESULTS: Of 150 patients with symptomatic extracranial ICA stenosis of ≥50%, 100 preferred best medical management (m = 75, f = 25) and 50 (m = 37, f = 13) opted for carotid intervention. The mean age of the patient cohort was 59.8 ± 12.7. Follow-up was done at regular intervals from 3 months to 1 year. In the medical group, the recurrence occurred in 10 patients; 4 (40%) within 6 months, 5 (50%) within 6–12 months, and 1 (10%) after 1 year. In the intervention group, the recurrence occurred in 6 patients; 5 (83%) within the first 6 months and 1 (17%) within 6–12 months. CONCLUSIONS: Overall, there was no statistically significant difference in the rate of recurrence between the best medical management and the carotid interventional procedures. |
format | Online Article Text |
id | pubmed-6137635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61376352018-09-26 Comparison of Best Medical Management with Carotid Intervention Procedures in the Prevention of Stroke Recurrence in Patients with Symptomatic Internal Carotid Artery Stenosis Deepa Rani, BV Gampa, Sandeep Sirineni, Deepika Harshavardhana, K. R. Krishna, Satya Rama Kaul, Subhash Ann Indian Acad Neurol Original Article BACKGROUND: As per the current recommendations, carotid interventional procedures (carotid endarterectomy/carotid artery stenting) are considered superior to medical management in reducing the stroke recurrence in patients with symptomatic extracranial internal carotid artery (ICA) stenosis. OBJECTIVE: The objective of this study is to compare the best medical management with carotid interventional procedures in the prevention of stroke recurrence in the patients with symptomatic extracranial ICA stenosis. MATERIALS AND METHODS: This was a parallel, prospective, two-arm, open-label, observational study. Participants were selected consecutively and prospectively among patients from Outpatient and Inpatient Departments of Neurology at Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India. The study period was from January 2012 to December 2017. RESULTS: Of 150 patients with symptomatic extracranial ICA stenosis of ≥50%, 100 preferred best medical management (m = 75, f = 25) and 50 (m = 37, f = 13) opted for carotid intervention. The mean age of the patient cohort was 59.8 ± 12.7. Follow-up was done at regular intervals from 3 months to 1 year. In the medical group, the recurrence occurred in 10 patients; 4 (40%) within 6 months, 5 (50%) within 6–12 months, and 1 (10%) after 1 year. In the intervention group, the recurrence occurred in 6 patients; 5 (83%) within the first 6 months and 1 (17%) within 6–12 months. CONCLUSIONS: Overall, there was no statistically significant difference in the rate of recurrence between the best medical management and the carotid interventional procedures. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6137635/ /pubmed/30258258 http://dx.doi.org/10.4103/aian.AIAN_124_18 Text en Copyright: © 2018 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Deepa Rani, BV Gampa, Sandeep Sirineni, Deepika Harshavardhana, K. R. Krishna, Satya Rama Kaul, Subhash Comparison of Best Medical Management with Carotid Intervention Procedures in the Prevention of Stroke Recurrence in Patients with Symptomatic Internal Carotid Artery Stenosis |
title | Comparison of Best Medical Management with Carotid Intervention Procedures in the Prevention of Stroke Recurrence in Patients with Symptomatic Internal Carotid Artery Stenosis |
title_full | Comparison of Best Medical Management with Carotid Intervention Procedures in the Prevention of Stroke Recurrence in Patients with Symptomatic Internal Carotid Artery Stenosis |
title_fullStr | Comparison of Best Medical Management with Carotid Intervention Procedures in the Prevention of Stroke Recurrence in Patients with Symptomatic Internal Carotid Artery Stenosis |
title_full_unstemmed | Comparison of Best Medical Management with Carotid Intervention Procedures in the Prevention of Stroke Recurrence in Patients with Symptomatic Internal Carotid Artery Stenosis |
title_short | Comparison of Best Medical Management with Carotid Intervention Procedures in the Prevention of Stroke Recurrence in Patients with Symptomatic Internal Carotid Artery Stenosis |
title_sort | comparison of best medical management with carotid intervention procedures in the prevention of stroke recurrence in patients with symptomatic internal carotid artery stenosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137635/ https://www.ncbi.nlm.nih.gov/pubmed/30258258 http://dx.doi.org/10.4103/aian.AIAN_124_18 |
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