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Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma
Paronychia is a painful inflammatory disorder of the nail fold. Periungual pyogenic granuloma – a benign vascular tumor of the capillaries – can develop as a complication of paronychia. We report both, paronychia and periungual pyogenic granuloma, as possible adverse events during systemic drug-ther...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137670/ https://www.ncbi.nlm.nih.gov/pubmed/30258794 http://dx.doi.org/10.4103/idoj.IDOJ_133_18 |
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author | Wollina, Uwe |
author_facet | Wollina, Uwe |
author_sort | Wollina, Uwe |
collection | PubMed |
description | Paronychia is a painful inflammatory disorder of the nail fold. Periungual pyogenic granuloma – a benign vascular tumor of the capillaries – can develop as a complication of paronychia. We report both, paronychia and periungual pyogenic granuloma, as possible adverse events during systemic drug-therapy. The following groups of systemic drugs have been considered: taxanes, epidermal growth factor-receptor (EGFR) inhibitors, EGFR tyrosine kinase inhibitors, tyrosine kinase inhibitors, inhibitors of MEK/ERK, BRAF inhibitors, CD20 antagonists, vascular endothelial growth factor inhibitors, and retinoids. Recommendations for prevention and treatment are given. Since paronychia is a painful inflammatory disorder that has a negative impact on daily activities, early recognition and adequate treatment improve adhesion to treatment and quality of life. |
format | Online Article Text |
id | pubmed-6137670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61376702018-09-26 Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma Wollina, Uwe Indian Dermatol Online J Review Article Paronychia is a painful inflammatory disorder of the nail fold. Periungual pyogenic granuloma – a benign vascular tumor of the capillaries – can develop as a complication of paronychia. We report both, paronychia and periungual pyogenic granuloma, as possible adverse events during systemic drug-therapy. The following groups of systemic drugs have been considered: taxanes, epidermal growth factor-receptor (EGFR) inhibitors, EGFR tyrosine kinase inhibitors, tyrosine kinase inhibitors, inhibitors of MEK/ERK, BRAF inhibitors, CD20 antagonists, vascular endothelial growth factor inhibitors, and retinoids. Recommendations for prevention and treatment are given. Since paronychia is a painful inflammatory disorder that has a negative impact on daily activities, early recognition and adequate treatment improve adhesion to treatment and quality of life. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6137670/ /pubmed/30258794 http://dx.doi.org/10.4103/idoj.IDOJ_133_18 Text en Copyright: © 2018 Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Wollina, Uwe Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma |
title | Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma |
title_full | Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma |
title_fullStr | Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma |
title_full_unstemmed | Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma |
title_short | Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma |
title_sort | systemic drug-induced chronic paronychia and periungual pyogenic granuloma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137670/ https://www.ncbi.nlm.nih.gov/pubmed/30258794 http://dx.doi.org/10.4103/idoj.IDOJ_133_18 |
work_keys_str_mv | AT wollinauwe systemicdruginducedchronicparonychiaandperiungualpyogenicgranuloma |