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Structural Basis of Homology-Directed DNA Repair Mediated by RAD52

RAD52 mediates homologous recombination by annealing cDNA strands. However, the detailed mechanism of DNA annealing promoted by RAD52 has remained elusive. Here we report two crystal structures of human RAD52 single-stranded DNA (ssDNA) complexes that probably represent key reaction intermediates of...

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Detalles Bibliográficos
Autores principales:	Saotome, Mika, Saito, Kengo, Yasuda, Takeshi, Ohtomo, Hideaki, Sugiyama, Shusei, Nishimura, Yoshifumi, Kurumizaka, Hitoshi, Kagawa, Wataru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137706/ https://www.ncbi.nlm.nih.gov/pubmed/30428330 http://dx.doi.org/10.1016/j.isci.2018.04.005

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