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Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study

BACKGROUND: Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and...

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Autores principales: Ai, Leo, Bansal, Priya, Mueller, Jerel K., Legon, Wynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137744/
https://www.ncbi.nlm.nih.gov/pubmed/30217150
http://dx.doi.org/10.1186/s12868-018-0456-6
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author Ai, Leo
Bansal, Priya
Mueller, Jerel K.
Legon, Wynn
author_facet Ai, Leo
Bansal, Priya
Mueller, Jerel K.
Legon, Wynn
author_sort Ai, Leo
collection PubMed
description BACKGROUND: Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI to extend these findings. We test the effect of tFUS on 7T BOLD fMRI signals from individual finger representations in the human primary motor cortex (M1) and connected cortical motor regions. Participants (N = 5) performed a cued finger tapping task in a 7T MRI scanner with their thumb, index, and middle fingers to produce a BOLD signal for individual M1 finger representations during either tFUS or sham neuromodulation to the thumb representation. RESULTS: Results demonstrated a statistically significant increase in activation volume of the M1 thumb representation for the tFUS condition as compared to sham. No differences in percent BOLD changes were found. This effect was spatially confined as the index and middle finger M1 finger representations did not show similar significant changes in either percent change or activation volume. No effects were seen during tFUS to M1 in the supplementary motor area or the dorsal premotor cortex. CONCLUSIONS: Single element tFUS can be paired with high field MRI that does not induce significant artifact. tFUS increases activation volumes of the targeted finger representation that is spatially restricted within M1 but does not extend to functionally connected motor regions. Trial registration ClinicalTrials.gov NCT03634631 08/14/18
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spelling pubmed-61377442018-09-15 Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study Ai, Leo Bansal, Priya Mueller, Jerel K. Legon, Wynn BMC Neurosci Research Article BACKGROUND: Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI to extend these findings. We test the effect of tFUS on 7T BOLD fMRI signals from individual finger representations in the human primary motor cortex (M1) and connected cortical motor regions. Participants (N = 5) performed a cued finger tapping task in a 7T MRI scanner with their thumb, index, and middle fingers to produce a BOLD signal for individual M1 finger representations during either tFUS or sham neuromodulation to the thumb representation. RESULTS: Results demonstrated a statistically significant increase in activation volume of the M1 thumb representation for the tFUS condition as compared to sham. No differences in percent BOLD changes were found. This effect was spatially confined as the index and middle finger M1 finger representations did not show similar significant changes in either percent change or activation volume. No effects were seen during tFUS to M1 in the supplementary motor area or the dorsal premotor cortex. CONCLUSIONS: Single element tFUS can be paired with high field MRI that does not induce significant artifact. tFUS increases activation volumes of the targeted finger representation that is spatially restricted within M1 but does not extend to functionally connected motor regions. Trial registration ClinicalTrials.gov NCT03634631 08/14/18 BioMed Central 2018-09-14 /pmc/articles/PMC6137744/ /pubmed/30217150 http://dx.doi.org/10.1186/s12868-018-0456-6 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ai, Leo
Bansal, Priya
Mueller, Jerel K.
Legon, Wynn
Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study
title Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study
title_full Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study
title_fullStr Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study
title_full_unstemmed Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study
title_short Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study
title_sort effects of transcranial focused ultrasound on human primary motor cortex using 7t fmri: a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137744/
https://www.ncbi.nlm.nih.gov/pubmed/30217150
http://dx.doi.org/10.1186/s12868-018-0456-6
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