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MARDy: Mycology Antifungal Resistance Database

SUMMARY: The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns, it is important to understand the mechanisms that cause antifungal resistance. The curated Mycology Antifungal Resistance Databas...

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Autores principales: Nash, Anthony, Sewell, Thomas, Farrer, Rhys A, Abdolrasouli, Alireza, Shelton, Jennifer M G, Fisher, Matthew C, Rhodes, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137992/
https://www.ncbi.nlm.nih.gov/pubmed/29897419
http://dx.doi.org/10.1093/bioinformatics/bty321
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author Nash, Anthony
Sewell, Thomas
Farrer, Rhys A
Abdolrasouli, Alireza
Shelton, Jennifer M G
Fisher, Matthew C
Rhodes, Johanna
author_facet Nash, Anthony
Sewell, Thomas
Farrer, Rhys A
Abdolrasouli, Alireza
Shelton, Jennifer M G
Fisher, Matthew C
Rhodes, Johanna
author_sort Nash, Anthony
collection PubMed
description SUMMARY: The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns, it is important to understand the mechanisms that cause antifungal resistance. The curated Mycology Antifungal Resistance Database (MARDy) is a web-service of antifungal drug resistance mechanisms, including amino acid substitutions, tandem repeat sequences and genome ploidy. MARDy is implemented on a Linux, Apache, MySQL and PHP web development platform and includes a local installation of BLASTn of the database of curated genes. AVAILABILITY AND IMPLEMENTATION: MARDy can be accessed at http://www.mardy.net and is free to use. The complete database can be retrieved, ordered by organism, gene and drug. Missing or new mycological antifungal resistance data can be relayed to the development team through a contribute entry form. Updates and news will be publicized via a dedicated Twitter feed: @MARDYfungi.
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spelling pubmed-61379922018-09-24 MARDy: Mycology Antifungal Resistance Database Nash, Anthony Sewell, Thomas Farrer, Rhys A Abdolrasouli, Alireza Shelton, Jennifer M G Fisher, Matthew C Rhodes, Johanna Bioinformatics Applications Notes SUMMARY: The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns, it is important to understand the mechanisms that cause antifungal resistance. The curated Mycology Antifungal Resistance Database (MARDy) is a web-service of antifungal drug resistance mechanisms, including amino acid substitutions, tandem repeat sequences and genome ploidy. MARDy is implemented on a Linux, Apache, MySQL and PHP web development platform and includes a local installation of BLASTn of the database of curated genes. AVAILABILITY AND IMPLEMENTATION: MARDy can be accessed at http://www.mardy.net and is free to use. The complete database can be retrieved, ordered by organism, gene and drug. Missing or new mycological antifungal resistance data can be relayed to the development team through a contribute entry form. Updates and news will be publicized via a dedicated Twitter feed: @MARDYfungi. Oxford University Press 2018-09-15 2018-04-20 /pmc/articles/PMC6137992/ /pubmed/29897419 http://dx.doi.org/10.1093/bioinformatics/bty321 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Applications Notes
Nash, Anthony
Sewell, Thomas
Farrer, Rhys A
Abdolrasouli, Alireza
Shelton, Jennifer M G
Fisher, Matthew C
Rhodes, Johanna
MARDy: Mycology Antifungal Resistance Database
title MARDy: Mycology Antifungal Resistance Database
title_full MARDy: Mycology Antifungal Resistance Database
title_fullStr MARDy: Mycology Antifungal Resistance Database
title_full_unstemmed MARDy: Mycology Antifungal Resistance Database
title_short MARDy: Mycology Antifungal Resistance Database
title_sort mardy: mycology antifungal resistance database
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137992/
https://www.ncbi.nlm.nih.gov/pubmed/29897419
http://dx.doi.org/10.1093/bioinformatics/bty321
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