RANGER-DTL 2.0: rigorous reconstruction of gene-family evolution by duplication, transfer and loss

SUMMARY: RANGER-DTL 2.0 is a software program for inferring gene family evolution using Duplication-Transfer-Loss reconciliation. This new software is highly scalable and easy to use, and offers many new features not currently available in any other reconciliation program. RANGER-DTL 2.0 has a parti...

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Detalles Bibliográficos
Autores principales: Bansal, Mukul S, Kellis, Manolis, Kordi, Misagh, Kundu, Soumya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137995/
https://www.ncbi.nlm.nih.gov/pubmed/29688310
http://dx.doi.org/10.1093/bioinformatics/bty314
Descripción
Sumario:SUMMARY: RANGER-DTL 2.0 is a software program for inferring gene family evolution using Duplication-Transfer-Loss reconciliation. This new software is highly scalable and easy to use, and offers many new features not currently available in any other reconciliation program. RANGER-DTL 2.0 has a particular focus on reconciliation accuracy and can account for many sources of reconciliation uncertainty including uncertain gene tree rooting, gene tree topological uncertainty, multiple optimal reconciliations and alternative event cost assignments. RANGER-DTL 2.0 is open-source and written in C++ and Python. AVAILABILITY AND IMPLEMENTATION: Pre-compiled executables, source code (open-source under GNU GPL) and a detailed manual are freely available from http://compbio.engr.uconn.edu/software/RANGER-DTL/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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