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Electroconvulsive Therapy and Risk of Dementia—A Nationwide Cohort Study in Taiwan

Background: Electroconvulsive therapy (ECT) is an effective treatment for schizophrenia, bipolar disorder, and major depressive disorder, and a temporary memory loss may occur after ECT. However, the association between ECT in patients with schizophrenia, bipolar disorder, and major depressive disor...

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Autores principales: Chu, Ching-Wen, Chien, Wu-Chien, Chung, Chi-Hsiang, Chao, Pei-Chun, Chang, Hsin-An, Kao, Yu-Chen, Chou, Yu-Ching, Tzeng, Nian-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138057/
https://www.ncbi.nlm.nih.gov/pubmed/30245639
http://dx.doi.org/10.3389/fpsyt.2018.00397
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author Chu, Ching-Wen
Chien, Wu-Chien
Chung, Chi-Hsiang
Chao, Pei-Chun
Chang, Hsin-An
Kao, Yu-Chen
Chou, Yu-Ching
Tzeng, Nian-Sheng
author_facet Chu, Ching-Wen
Chien, Wu-Chien
Chung, Chi-Hsiang
Chao, Pei-Chun
Chang, Hsin-An
Kao, Yu-Chen
Chou, Yu-Ching
Tzeng, Nian-Sheng
author_sort Chu, Ching-Wen
collection PubMed
description Background: Electroconvulsive therapy (ECT) is an effective treatment for schizophrenia, bipolar disorder, and major depressive disorder, and a temporary memory loss may occur after ECT. However, the association between ECT in patients with schizophrenia, bipolar disorder, and major depressive disorder, and the risk of dementia is yet to be examined. Objective: This study aimed to clarify as to whether ECT is associated with the risk of dementia after ECT in patients with schizophrenia, bipolar disorder, and major depressive disorder, using Taiwan's National Health Insurance Research Database (NHIRD). Methods: A total of 3,796 enrolled participants (schizophrenia, 46.68%; bipolar disorder, 11.77%; and major depressive disorder, 41.55%) with 994 patients who had received ECT and 2,982 controls matched for sex and age, between January 1, and December 31, 2000, were selected from the NHIRD. After adjusting for confounding factors, Fine and Gray's survival analysis was used to compare the risk of developing dementia during the 10 years of follow-up. Results: Of the study patients, 45 (4.53%) of them developed dementia when compared to 149 (5.0%) in the control group. Fine and Gray's survival analysis revealed that the study patients were not associated with an increased risk of dementia [hazard ratio (HR) = 0.612, 95% confidence interval (CI) = 0.438–1.854, P = 0.325]. After adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities, the adjusted HR was 0.633 (95% CI = 0.448 – 1.895, P = 0.304). Conclusion: This study supports that ECT was not associated with the increased risk of dementia in patients with schizophrenia, bipolar disorder, and major depressive disorder, using the NHIRD.
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spelling pubmed-61380572018-09-21 Electroconvulsive Therapy and Risk of Dementia—A Nationwide Cohort Study in Taiwan Chu, Ching-Wen Chien, Wu-Chien Chung, Chi-Hsiang Chao, Pei-Chun Chang, Hsin-An Kao, Yu-Chen Chou, Yu-Ching Tzeng, Nian-Sheng Front Psychiatry Psychiatry Background: Electroconvulsive therapy (ECT) is an effective treatment for schizophrenia, bipolar disorder, and major depressive disorder, and a temporary memory loss may occur after ECT. However, the association between ECT in patients with schizophrenia, bipolar disorder, and major depressive disorder, and the risk of dementia is yet to be examined. Objective: This study aimed to clarify as to whether ECT is associated with the risk of dementia after ECT in patients with schizophrenia, bipolar disorder, and major depressive disorder, using Taiwan's National Health Insurance Research Database (NHIRD). Methods: A total of 3,796 enrolled participants (schizophrenia, 46.68%; bipolar disorder, 11.77%; and major depressive disorder, 41.55%) with 994 patients who had received ECT and 2,982 controls matched for sex and age, between January 1, and December 31, 2000, were selected from the NHIRD. After adjusting for confounding factors, Fine and Gray's survival analysis was used to compare the risk of developing dementia during the 10 years of follow-up. Results: Of the study patients, 45 (4.53%) of them developed dementia when compared to 149 (5.0%) in the control group. Fine and Gray's survival analysis revealed that the study patients were not associated with an increased risk of dementia [hazard ratio (HR) = 0.612, 95% confidence interval (CI) = 0.438–1.854, P = 0.325]. After adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities, the adjusted HR was 0.633 (95% CI = 0.448 – 1.895, P = 0.304). Conclusion: This study supports that ECT was not associated with the increased risk of dementia in patients with schizophrenia, bipolar disorder, and major depressive disorder, using the NHIRD. Frontiers Media S.A. 2018-09-07 /pmc/articles/PMC6138057/ /pubmed/30245639 http://dx.doi.org/10.3389/fpsyt.2018.00397 Text en Copyright © 2018 Chu, Chien, Chung, Chao, Chang, Kao, Chou and Tzeng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Chu, Ching-Wen
Chien, Wu-Chien
Chung, Chi-Hsiang
Chao, Pei-Chun
Chang, Hsin-An
Kao, Yu-Chen
Chou, Yu-Ching
Tzeng, Nian-Sheng
Electroconvulsive Therapy and Risk of Dementia—A Nationwide Cohort Study in Taiwan
title Electroconvulsive Therapy and Risk of Dementia—A Nationwide Cohort Study in Taiwan
title_full Electroconvulsive Therapy and Risk of Dementia—A Nationwide Cohort Study in Taiwan
title_fullStr Electroconvulsive Therapy and Risk of Dementia—A Nationwide Cohort Study in Taiwan
title_full_unstemmed Electroconvulsive Therapy and Risk of Dementia—A Nationwide Cohort Study in Taiwan
title_short Electroconvulsive Therapy and Risk of Dementia—A Nationwide Cohort Study in Taiwan
title_sort electroconvulsive therapy and risk of dementia—a nationwide cohort study in taiwan
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138057/
https://www.ncbi.nlm.nih.gov/pubmed/30245639
http://dx.doi.org/10.3389/fpsyt.2018.00397
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