PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies

KEY POINTS: The carotid body is a peripheral arterial chemoreceptor that regulates ventilation in response to both acute and sustained hypoxia. Type I cells in this organ respond to low oxygen both acutely by depolarization and dense core vesicle secretion and, over the longer term, via cellular pro...

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Detalles Bibliográficos
Autores principales: Fielding, James W., Hodson, Emma J., Cheng, Xiaotong, Ferguson, David J. P., Eckardt, Luise, Adam, Julie, Lip, Philomena, Maton‐Howarth, Matthew, Ratnayaka, Indrika, Pugh, Christopher W., Buckler, Keith J., Ratcliffe, Peter J., Bishop, Tammie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Respiratory
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138294/
https://www.ncbi.nlm.nih.gov/pubmed/29917232
http://dx.doi.org/10.1113/JP275996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138294/
https://www.ncbi.nlm.nih.gov/pubmed/29917232
http://dx.doi.org/10.1113/JP275996

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