TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy

Sequestration of protein aggregates in inclusion bodies and their subsequent degradation prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying molecular mechanisms controlling the turnover of protein aggregates are mostly uncharacterized. Herein, we show that a TRIM fami...

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Detalles Bibliográficos
Autores principales: Jena, Kautilya Kumar, Kolapalli, Srinivasa Prasad, Mehto, Subhash, Nath, Parej, Das, Biswajit, Sahoo, Pradyumna Kumar, Ahad, Abdul, Syed, Gulam Hussain, Raghav, Sunil K, Senapati, Shantibhusan, Chauhan, Swati, Chauhan, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138442/
https://www.ncbi.nlm.nih.gov/pubmed/30143514
http://dx.doi.org/10.15252/embj.201798358

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