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In vivo affinity and target engagement in skin and blood in a first‐time‐in‐human study of an anti‐oncostatin M monoclonal antibody

AIMS: The oncostatin M (OSM) pathway drives fibrosis, inflammation and vasculopathy, and is a potential therapeutic target for inflammatory and fibrotic diseases. The aim of this first‐time‐in‐human experimental medicine study was to assess the safety, tolerability, pharmacokinetics and target engag...

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Detalles Bibliográficos
Autores principales:	Reid, Juliet, Zamuner, Stefano, Edwards, Ken, Rumley, Sally‐Anne, Nevin, Katherine, Feeney, Maria, Zecchin, Chiara, Fernando, Disala, Wisniacki, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138480/ https://www.ncbi.nlm.nih.gov/pubmed/29900565 http://dx.doi.org/10.1111/bcp.13669

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