Cargando…

Management of rifampicin mono‐resistant tuberculosis in Queensland, Australia: a retrospective case series

Rifampicin mono‐resistant tuberculosis (RMR‐TB) is rare worldwide; however, it is associated with poor treatment outcomes. Evidence to guide the treatment of RMR‐TB is lacking. International guidelines have recently changed and now recommend that RMR‐TB should be managed with multi‐drug‐resistant tu...

Descripción completa

Detalles Bibliográficos
Autores principales: Gibson, Justine, Donnan, Ellen, Eather, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138512/
https://www.ncbi.nlm.nih.gov/pubmed/30237887
http://dx.doi.org/10.1002/rcr2.366
_version_ 1783355353135579136
author Gibson, Justine
Donnan, Ellen
Eather, Geoffrey
author_facet Gibson, Justine
Donnan, Ellen
Eather, Geoffrey
author_sort Gibson, Justine
collection PubMed
description Rifampicin mono‐resistant tuberculosis (RMR‐TB) is rare worldwide; however, it is associated with poor treatment outcomes. Evidence to guide the treatment of RMR‐TB is lacking. International guidelines have recently changed and now recommend that RMR‐TB should be managed with multi‐drug‐resistant tuberculosis (MDR‐TB) regimens. This report is a retrospective review of all cases of RMR‐TB in Queensland, Australia, from 2000 to 2016 to assess treatment outcomes and regimens used. Twelve cases of RMR‐TB were diagnosed, with seven patients completing treatment in Queensland. This study confirms that RMR‐TB is rare in Queensland. Generally extended regimens with first‐line agents +/− a fluoroquinolone were used, and all patients who completed treatment in Queensland had successful outcomes.
format Online
Article
Text
id pubmed-6138512
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley & Sons, Ltd
record_format MEDLINE/PubMed
spelling pubmed-61385122018-09-20 Management of rifampicin mono‐resistant tuberculosis in Queensland, Australia: a retrospective case series Gibson, Justine Donnan, Ellen Eather, Geoffrey Respirol Case Rep Case Series Rifampicin mono‐resistant tuberculosis (RMR‐TB) is rare worldwide; however, it is associated with poor treatment outcomes. Evidence to guide the treatment of RMR‐TB is lacking. International guidelines have recently changed and now recommend that RMR‐TB should be managed with multi‐drug‐resistant tuberculosis (MDR‐TB) regimens. This report is a retrospective review of all cases of RMR‐TB in Queensland, Australia, from 2000 to 2016 to assess treatment outcomes and regimens used. Twelve cases of RMR‐TB were diagnosed, with seven patients completing treatment in Queensland. This study confirms that RMR‐TB is rare in Queensland. Generally extended regimens with first‐line agents +/− a fluoroquinolone were used, and all patients who completed treatment in Queensland had successful outcomes. John Wiley & Sons, Ltd 2018-09-14 /pmc/articles/PMC6138512/ /pubmed/30237887 http://dx.doi.org/10.1002/rcr2.366 Text en © 2018 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Gibson, Justine
Donnan, Ellen
Eather, Geoffrey
Management of rifampicin mono‐resistant tuberculosis in Queensland, Australia: a retrospective case series
title Management of rifampicin mono‐resistant tuberculosis in Queensland, Australia: a retrospective case series
title_full Management of rifampicin mono‐resistant tuberculosis in Queensland, Australia: a retrospective case series
title_fullStr Management of rifampicin mono‐resistant tuberculosis in Queensland, Australia: a retrospective case series
title_full_unstemmed Management of rifampicin mono‐resistant tuberculosis in Queensland, Australia: a retrospective case series
title_short Management of rifampicin mono‐resistant tuberculosis in Queensland, Australia: a retrospective case series
title_sort management of rifampicin mono‐resistant tuberculosis in queensland, australia: a retrospective case series
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138512/
https://www.ncbi.nlm.nih.gov/pubmed/30237887
http://dx.doi.org/10.1002/rcr2.366
work_keys_str_mv AT gibsonjustine managementofrifampicinmonoresistanttuberculosisinqueenslandaustraliaaretrospectivecaseseries
AT donnanellen managementofrifampicinmonoresistanttuberculosisinqueenslandaustraliaaretrospectivecaseseries
AT eathergeoffrey managementofrifampicinmonoresistanttuberculosisinqueenslandaustraliaaretrospectivecaseseries