Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle

Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway...

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Detalles Bibliográficos
Autores principales: Coggan, Andrew R., Peterson, Linda R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138552/
https://www.ncbi.nlm.nih.gov/pubmed/30001275
http://dx.doi.org/10.1249/JES.0000000000000167
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author Coggan, Andrew R.
Peterson, Linda R.
author_facet Coggan, Andrew R.
Peterson, Linda R.
author_sort Coggan, Andrew R.
collection PubMed
description Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca(2+) concentration along with the Ca(2+) sensitivity of the myofilaments themselves.
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spelling pubmed-61385522018-09-28 Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle Coggan, Andrew R. Peterson, Linda R. Exerc Sport Sci Rev Articles Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca(2+) concentration along with the Ca(2+) sensitivity of the myofilaments themselves. Lippincott Williams & Wilkins 2018-10 2018-09-14 /pmc/articles/PMC6138552/ /pubmed/30001275 http://dx.doi.org/10.1249/JES.0000000000000167 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Articles
Coggan, Andrew R.
Peterson, Linda R.
Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle
title Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle
title_full Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle
title_fullStr Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle
title_full_unstemmed Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle
title_short Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle
title_sort dietary nitrate enhances the contractile properties of human skeletal muscle
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138552/
https://www.ncbi.nlm.nih.gov/pubmed/30001275
http://dx.doi.org/10.1249/JES.0000000000000167
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