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Modular DNA strand-displacement controllers for directing material expansion
Soft materials that swell or change shape in response to external stimuli show extensive promise in regenerative medicine, targeted therapeutics, and soft robotics. Generally, a stimulus for shape change must interact directly with the material, limiting the types of stimuli that may be used and nec...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138645/ https://www.ncbi.nlm.nih.gov/pubmed/30217991 http://dx.doi.org/10.1038/s41467-018-06218-w |
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author | Fern, Joshua Schulman, Rebecca |
author_facet | Fern, Joshua Schulman, Rebecca |
author_sort | Fern, Joshua |
collection | PubMed |
description | Soft materials that swell or change shape in response to external stimuli show extensive promise in regenerative medicine, targeted therapeutics, and soft robotics. Generally, a stimulus for shape change must interact directly with the material, limiting the types of stimuli that may be used and necessitating high stimulus concentrations. Here, we show how DNA strand-displacement controllers within hydrogels can mediate size change by interpreting, amplifying, and integrating stimuli and releasing signals that direct the response. These controllers tune the time scale and degree of DNA-crosslinked hydrogel swelling and can actuate dramatic material size change in response to <100 nM of a specific biomolecular input. Controllers can also direct swelling in response to small molecules or perform logic. The integration of these stimuli-responsive materials with biomolecular circuits is a major step towards autonomous soft robotic systems in which sensing and actuation are implemented by biomolecular reaction networks. |
format | Online Article Text |
id | pubmed-6138645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61386452018-09-17 Modular DNA strand-displacement controllers for directing material expansion Fern, Joshua Schulman, Rebecca Nat Commun Article Soft materials that swell or change shape in response to external stimuli show extensive promise in regenerative medicine, targeted therapeutics, and soft robotics. Generally, a stimulus for shape change must interact directly with the material, limiting the types of stimuli that may be used and necessitating high stimulus concentrations. Here, we show how DNA strand-displacement controllers within hydrogels can mediate size change by interpreting, amplifying, and integrating stimuli and releasing signals that direct the response. These controllers tune the time scale and degree of DNA-crosslinked hydrogel swelling and can actuate dramatic material size change in response to <100 nM of a specific biomolecular input. Controllers can also direct swelling in response to small molecules or perform logic. The integration of these stimuli-responsive materials with biomolecular circuits is a major step towards autonomous soft robotic systems in which sensing and actuation are implemented by biomolecular reaction networks. Nature Publishing Group UK 2018-09-14 /pmc/articles/PMC6138645/ /pubmed/30217991 http://dx.doi.org/10.1038/s41467-018-06218-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Fern, Joshua Schulman, Rebecca Modular DNA strand-displacement controllers for directing material expansion |
title | Modular DNA strand-displacement controllers for directing material expansion |
title_full | Modular DNA strand-displacement controllers for directing material expansion |
title_fullStr | Modular DNA strand-displacement controllers for directing material expansion |
title_full_unstemmed | Modular DNA strand-displacement controllers for directing material expansion |
title_short | Modular DNA strand-displacement controllers for directing material expansion |
title_sort | modular dna strand-displacement controllers for directing material expansion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138645/ https://www.ncbi.nlm.nih.gov/pubmed/30217991 http://dx.doi.org/10.1038/s41467-018-06218-w |
work_keys_str_mv | AT fernjoshua modulardnastranddisplacementcontrollersfordirectingmaterialexpansion AT schulmanrebecca modulardnastranddisplacementcontrollersfordirectingmaterialexpansion |