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AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage

Glycine N-methyltransferase (GNMT) is abundantly expressed in normal livers and plays a protective role against tumor formation. GNMT depletion leads to progression of hepatocellular carcinoma (HCC). In this study, we investigated the activity of ectopic GNMT delivered using recombinant adeno-associ...

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Detalles Bibliográficos
Autores principales:	Fang, Cheng-Chieh, Wu, Ching-Fen, Liao, Yi-Jen, Huang, Shiu-Feng, Chen, Marcelo, Chen, Yi-Ming Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138656/ https://www.ncbi.nlm.nih.gov/pubmed/30217986 http://dx.doi.org/10.1038/s41598-018-30800-3

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